How do you synthesize clonazepam?

The synthesis of clonazepam begins with 2-chloro-2′nitrobenzophenon, which is reduced to 2-chloro-2′-aminobenzophenon (9.6. 1) by hydrogen over Raney nickel. The amino derivative is amidated by 2-bromoacetyl bromide to give the bromacetamide (9.6. 2) and is further converted into aminoacetamide (9.6.

What is the mode of action of clonazepam?

Clonazepam is a potent anticonvulsant 1,4-benzodiazepine that controls some types of myoclonus. Its primary mode of action is to facilitate GABAergic transmission in the brain by a direct effect on benzodiazepine receptors.

Does clonazepam make you sleepy?

Clonazepam works by increasing levels of a calming chemical in your brain. This can relieve anxiety, stop seizures and fits or relax tense muscles. The most common side effect is feeling sleepy (drowsy) during the daytime. Clonazepam is not likely to be addictive if you take it for a short time (2 to 4 weeks).

How do you synthesize benzodiazepines?

Benzodiazepines are generally synthesized by the condensation of o-phenylenediamine (OPDA) with a,b-unsaturated carbonyl compounds, b-haloketones, or with ketones [12] using acidic catalysts which are critical to enhance the condensation process.

Is clonazepam good for anxiety?

Clonazepam is a benzodiazepine. It is approved for the treatment of panic disorder (with or without agoraphobia), as well as certain types of seizure disorders. However, benzodiazepines are also commonly used to treat difficulty sleeping and alcohol withdrawal.

Is clonazepam 0.5 mg a sleeping pill?

Is clonazepam (Klonopin) a sleeping pill? No. Clonazepam (Klonopin) is approved by the FDA for anxiety and panic disorders, not insomnia. A common side effect is drowsiness, so a lot of people have taken clonazepam (Klonopin) to help them sleep.

How fast does clonazepam work for anxiety?

6. Response and effectiveness. Clonazepam takes approximately 20-60 minutes to start working. The peak effects of clonazepam are reached in 1-4 hours.

How do you synthesize diazepam?

Diazepam (personal experience) Dissolve 180 g 2-methylamino-5-chlorobenzophenone in 1 l dry dichloromethane, add 100 g chloroacetyl chloride over 1 h and reflux 10 h.