How do you remember metastases?

Tumors that metastasize to bone may be remembered using the mnemonic acronym “lead kettle” spelled PBKTL (“Pb” from the Latin plumbum, lead, ergo Pb on the Periodic Table).

Which cancers cause osteoblastic metastases?

Osteoblastic (or sclerotic), characterized by deposition of new bone, present in prostate cancer, carcinoid, small cell lung cancer, Hodgkin lymphoma or medulloblastoma.

What is osteoblastic metastasis?

Osteoblastic metastases develop when cancer cells invade the bone and cause too many bone cells to form. The bone becomes very dense (sclerotic). Osteoblastic metastases often happen when prostate cancer spreads to the bone.

What are the five most common sources of cancer metastatic to bone?

Almost all cancers can spread to the bone, but cancers that often spread there include breast, lung, prostate, kidney, melanoma, ovarian, and thyroid. The spine is the most common site for bone metastases.

What is paraneoplastic syndrome?

Paraneoplastic syndromes are a group of rare disorders that are triggered by an abnormal immune system response to a cancerous tumor known as a “neoplasm.” Paraneoplastic syndromes are thought to happen when cancer-fighting antibodies or white blood cells (known as T cells) mistakenly attack normal cells in the nervous …

What are lytic or blastic lesions?

There are two types of lesions: lytic lesions, which destroy bone material; and blastic lesions, which fill the bone with extra cells. Normal bone is constantly being remodeled, or broken down and rebuilt.

What does osteoblastic mean?

the formation of bone
Medical Definition of osteoblastic 1 : relating to or involving the formation of bone. 2 : composed of or being osteoblasts.

What stimulates osteoblast activity?

MSC Differentiation Into Osteoblasts Osx stimulates osteoblast bone-forming activity, and its protein expression levels would determine osteoblast differentiation stage. Runx2 activity can be regulated via protein–protein interaction with other transcription factors.

Can bone cancer spread to the brain?

The primary malignant bone tumors discussed are the most commonly reported to metastasize to the brain: osteosarcoma (osteogenic sarcoma), Ewing’s sarcoma, chondrosarcoma, chordoma, and fibroblastic/fibrohistiocytic tumors.