How do you make paracetamol with 4-aminophenol?

Paracetamol is made by reacting 4-aminophenol with ethanoic anhydride (more commonly called acetic anhydride). This reaction forms an amide bond and ethanoic acid as a by- product. When the reaction is complete the paracetamol is then isolated and purified.

How does p-aminophenol react with acetic anhydride?

In this case, p-aminophenol, the amine, is treated with acetic anhydride to form acetaminophen (p-acetamidophenol), the amide. Acetaminophen (paracetamol) an analgesic and fever-reducing medicine similar in effect to aspirin. It is an active ingredient in many over-the-counter medicines, including Tylenol and Midol.

Can paracetamol and acetic acid react?

As a result, when acetic acid (an acid) is added to p-aminophenol, the -NH2 group, which is basic, reacts faster with it in acid-base reaction yielding 4-acetamidophenol (or paracetamol) as the product.

How paracetamol is produced?

The starting material for the commercial manufacture of paracetamol is phenol, which is nitrated to give a mixture of the ortho and para-nitrotoluene. The o-isomer is removed by steam distillation, and the p-nitro group reduced to a p-amino group. This is then acetylated to give paracetamol.

How do you make paracetamol formula?

2.1. Production and occurrence. Paracetamol may be made by acetylation of para-aminophenol (obtained by reduction of para-nitrophenol) with acetic acid or acetic anhydride. A number of other synthetic routes have been described (Fairbrother, 1974).

How do you make paracetamol tablets?

In the proposed method for producing paracetamol tablets, including mixing and moistening the components of the tablet mass, wet granulation, drying the granulate, dry granulation and dusting of the granulate, when mixing and moistening the components of the tablet mass is carried out sequentially: first mix …

What happens when acetic anhydride is mixed with water?

The hydrolysis of acetic anhydride in the presence of water is an exothermic reaction that produces acetic acid.

Which functional group of 4-aminophenol is more reactive towards electrophiles?

In 4-aminophenol in alkaline medium phenolic OH is more reactive where as in Neutral medium NH2 is more reactive.

Does paracetamol react with water?

In these tablets the paracetamol has been mixed with citric acid (2-hydroxypropane-1,2,3-tricarboxylic acid) and sodium hydrogencarbonate (sodium bicarbonate). When placed in water, the citric acid and sodium hydrogencarbonate in the tablet react to produce bubbles of carbon dioxide.

What are the ingredients of paracetamol?

The active substance is paracetamol. Each tablet contains 500mg of paracetamol. The other ingredients are, maize starch, potassium sorbate, purified talc, stearic acid, povidone, and soluble starch.

Why is paracetamol not soluble in water?

Paracetamol as the name reveals has an aromatic ring, the phenol to be exact. This one has the OH-group, thanks to this functional group paracetamol is hygroscopic, that is to say it binds water, so much that this substance cannot be solved in water.