How do you give intrathecal methotrexate?

Intrathecal methotrexate is given through a needle which is inserted in one of the spaces between the bones in the lower back into the CSF, usually under general anaesthesia. This is known as a lumbar puncture. When drugs are given in this way, they are said to be given intrathecally.

Can you take methotrexate if you have MS?

Methotrexate is an immunosuppressant drug used in the treatment of cancer, arthritis and psoriasis. It is not a first line treatment for multiple sclerosis, but research has shown that it can reduce relapse rates and slow progression in people with MS.

What are the side effects of intrathecal chemotherapy?

What are the possible side effects of intrathecal chemotherapy?

  • weakness or tiredness.
  • back pain.
  • headache.
  • dizziness.
  • nausea and vomiting.
  • fever.
  • allergic reaction to chemotherapy medication.

How do you administer intrathecal?

A healthcare professional will administer intrathecal chemotherapy by injecting it into the spinal canal during a lumbar puncture. They may also administer it through a plastic insert called an Ommaya reservoir, which sits under the scalp.

How do you give an intrathecal injection?

Intrathecal injection

  1. You will sit and bend over or lie on your side.
  2. Your back will be carefully cleaned.
  3. The anesthesiologist will numb your skin.
  4. Once your skin is numb, the anesthesiologist places a special needle into your back and into the spinal space.
  5. He or she will inject the medicine into this space.

Does methotrexate affect memory?

Methotrexate causes persistent deficits in memory and executive function in a juvenile animal model. Neuropharmacology.

How often is intrathecal methotrexate given?

For treatment, in general, you’ll likely get two doses a week at first and then one weekly or monthly. The biologic rituximab, sometimes in combination with methotrexate, is used for some types of lymphoma.

Can a nurse administer intrathecal chemotherapy?

A chemotherapy trained nurse is a nurse who has been assessed to be competent both to administer intravenous chemotherapy and check both intravenous and intrathecal chemotherapy.