How do you calculate ampicillin-sulbactam?

-Unless otherwise specified, the dose is expressed as the total of ampicillin content (as the sodium salt) plus sulbactam content (as the sodium salt); the 1.5 g dose corresponds to 1 g ampicillin plus 500 mg sulbactam; the 3 g dose corresponds to 2 g ampicillin plus 1 g sulbactam.

What organisms does ampicillin-sulbactam cover?

Ampicillin/sulbactam combination shows synergy to cover strains of bacteria resistant to ampicillin, thus providing broader coverage. [1] Bacteria susceptible to ampicillin-sulbactam are Haemophilus influenzae, Escherichia coli, Acinetobacter, Klebsiella Staphylococcus aureus, Enterobacter, and anaerobes.

Does ampicillin-sulbactam cover Pseudomonas?

Abstract. Ampicillin-sulbactam has a wide range of antibacterial activity that includes Gram-positive and Gram-negative aerobic and anaerobic bacteria. However, the drug is not active against Pseudomonas aeruginosa and pathogens producing extended-spectrum beta-lactamases.

Does ampicillin-sulbactam cover MRSA?

Sulbactam, ampicillin and cefazolin at 32 micrograms/ml did not inhibit MRSA or MRSE. At 8 micrograms/ml of each agent all isolates were inhibited. Synergy of sulbactam and ampicillin could be demonstrated against MRSA by the agar fixed ratio method, checkerboard dilution and by killing curves.

How do you dilute UNASYN 1.5 g?

-Vials: Reconstitute 1.5 g vial with 3.2 ml or 3 g vial with 6.4 ml of sterile water for injection to give a solution containing 375 mg/ml ampicillin; sulbactam (250 mg of ampicillin and 125 mg of sulbactam per ml). Immediately further dilute.

Is ampicillin sulbactam equivalent to augmentin?

Augmentin (amoxicillin/clavulanate) and Unasyn (ampicillin sodium/sulbactam sodium) are both a combinations of penicillin-type antibiotics and beta-lactamase inhibitors used to treat various types of infections.

Is ampicillin sulbactam broad spectrum?

Ampicillin/sulbactam is a beta-lactam/beta-lactamase inhibitor combination with a broad spectrum of antibacterial activity against Gram-positive, Gram-negative and anaerobic bacteria.

Does ampicillin sulbactam cover staph?

Ampicillin/sulbactam is also used when the cause of an infection is not known (empiric therapy), such as intra-abdominal infections, skin infections, pneumonia, and gynecologic infections. It is active against a wide range of bacterial groups, including Staphylococcus aureus, Enterobacteriaceae, and anaerobic bacteria.

How do you dilute ampicillin for IV?

Add 1.5 ml water for injections to 500mg vial contents. Dissolve 500 mg in 10 ml water for injections. Administer by slow injection (three to four minutes). Ampicillin may also be added to infusion fluids or injected, suitably diluted, into the drip tube over a period of three to four minutes.

How do you dilute sulbactam injection?

UNASYN concentrations between 3 and 45 mg (2 to 30 mg ampicillin/1 to 15 mg sulbactam/mL) are recommended for intravenous use. The 15 gram vial may be reconstituted with either 92 mL Sterile Water for Injection or 0.9% Sodium Chloride Injection.

How much is sulbactam in UNASYN?

Initially, the vials may be reconstituted with Sterile Water for Injection to yield solutions containing 375 mg UNASYN per mL (250 mg ampicillin/125 mg sulbactam per mL).