How do you administer a succimer?

If the capsules cannot be swallowed, the contents of the capsule may be sprinkled on food and eaten immediately. The contents may also be given on a spoon and followed by a fruit drink. It is important to drink plenty of fluids while taking succimer.

What is succimer used to treat?

Succimer is used in the treatment of acute lead poisoning to remove excess lead from the body, especially in small children. Succimer combines with lead in the blood stream. The combination of lead and succimer is then removed from the body by the kidneys.

What is oral succimer?

Succimer (sux’ i mer) or dimercaptosuccinic acid (DMSA) is an orally available heavy metal chelating agent that is used to treat lead poisoning in children. Succimer is an organo-sulfur compound with two sulfhydryl groups that bind divalent metal ions such as lead, cadmium, mercury, and arsenic.

Is chemet the same as DMSA?

CHEMET (succimer) is an orally active, heavy metal chelating agent. The chemical name for succimer is meso 2, 3-dimercaptosuccinic acid (DMSA).

How do you take DMSA?

Take a DMSA capsule on 2 consecutive days each week on an empty stomach (e.g., Saturday and Sunday morning 1 hour before breakfast with a glass of water). The dose of the DMSA capsule will be given by the prescribing doctor.

What is the mechanism of action of succimer?

Succimer is a heavy metal chelator. It binds with high specificity to ions of lead in the blood to form a water-soluble complex that is subsequently excreted by the kidneys. Succimer can also chelate mercury, cadmium, and arsenic in this manner.

Does DMSA remove mercury from the brain?

DMSA increases urinary excretion of arsenic, cadmium, lead, methylmercury, and inorganic mercury, with removal from animals’ brains of lead and methylmercury.

Does DMSA remove iron?

DMSA has a large therapeutic window and is the least toxic amongst the dithiol compounds [40]. No significant loss of essential metals like zinc, iron, calcium and magnesium are observed.

When is the best time to take DMSA?

Should DMSA be taken with food?

Food should be withheld for 2 h to ensure efficient absorption of the DMSA. 0.5-1 L of purified water should be consumed during collection. Some patients may experience gas, bloating and/or loose stools with this protocol; such symptoms typically subside within 6 hours of dosing.

What is the antidote for digoxin toxicity?

Digoxin-specific antibody antigen-binding fragments (DSFab), brand name Digibind or Digifab, are an effective antidote that directly binds digoxin. DSFab is indicated for life-threatening toxicity including: Ventricular arrhythmias.