How do tolerogenic dendritic cells induce regulatory T cells?

Tolerogenic DCs (tDCs) participate to the establishment of T cell tolerance by a variety of mechanisms, including the induction of anergy, deletion of antigen-reactive T cells, stimulation of suppressive regulatory T cells (Tregs) either by activation of existing Tregs or de novo differentiation of Tregs from Tns and …

How can immune tolerance be induced?

Induced tolerance occurs when the immune system actively avoids responding to an external antigen. This immunological tolerance is induced by previous encounters with that antigen.

Which of the following is the mechanism for induction of immune tolerance?

Deletion is the major mechanism of self-tolerance induction during T-cell development in the thymus. Mature T cells in the peripheral lymphoid tissues can also be deleted under certain conditions.

What is the meaning of tolerogenic?

Producing immunological tolerance
[ tŏl′ər-ə-jĕn′ĭk ] adj. Producing immunological tolerance.

What are tolerogenic DCs?

Tolerogenic dendritic cells (a. k. a. tol-DCs, tDCs, or DCregs) are heterogenous pool of dendritic cells with immuno-suppressive properties, priming immune system into tolerogenic state against various antigens.

Do dendritic cells produce IL-2?

While not widely regarded as a significant provider of T-cell growth factors, DCs have previously been identified as a potential source of IL-2 cytokine. Recent research indicates that microbes are the most effective stimuli to trigger IL-2 production in DCs by activating the calcineurin/NFAT signaling pathway.

What is IL-2 and its role in T cell activation after an encounter with the target antigen?

IL-2 plays a dual role in T cell activation by stimulating the proliferation and differentiation of ‘conventional’ T cells as well as maintaining and expanding the population of ‘suppressive’ Treg cells (Fig.