How do thiazide diuretics affect blood glucose?

Present experience suggests that thiazide-induced impairment of glucose tolerance is due to both reduced glucose-stimulated insulin release and increased peripheral resistance to the action of insulin.

Do thiazide diuretics cause hyperglycemia?

In the meta-analysis by Zillich et al,8 there was a significant association between hypokalemia and hyperglycemia in patients treated with thiazide diuretics.

How does hydrochlorothiazide cause diabetes?

Conclusions. We have documented that HCTZ therapy leads to the development of hepatic steatosis and compromised insulin sensitivity in subjects at high risk for type 2 diabetes. Conversely, treatment with Valsartan did not cause ectopic fat redistribution, and in fact, leads to improved insulin sensitivity.

How do thiazide diuretics cause DKA?

In these patients, significant glucose rise can cause the development of DKA. In this case, the rapid rise in HgA1c in the weeks following thiazide use further supports that drug induced glucose dysregulation likely led to DKA.

How does hydrochlorothiazide affect blood glucose?

Abstract. A 20% or greater rise in the fasting blood sugar occurred in 11 of 24 patients treated with 50 mg hydrochlorothiazide twice daily for six to ten weeks. The blood sugar decreased when potassium was given in conjunction with the diuretic, but the mean fasting blood sugar remained higher than pretreatment levels …

Why thiazides are contraindicated in diabetes?

Prolonged thiazide diuretic therapy can lead to glucose intolerance and may occasionally precipitate diabetes mellitus. Short-term metabolic studies, epidemiologic studies, and a variety of clinical trials suggest a connection between ongoing thiazide diuretic use and the development of type 2 diabetes.

How do diuretics affect diabetes?

With the current dosages of thiazide diuretics being used in practice, the negative effect of the small increases in blood glucose levels is overshadowed by the beneficial effects seen in clinical trials using thiazides as part of the multidrug regimen that is required to achieve blood pressure control in most patients …

How does hydrochlorothiazide affect blood sugar?

Why do diuretics increase glucose?

Basically, diuretics can affect glucose levels in the blood because they impair glucose metabolism. When the body cannot break down glucose as it should, the glucose level in the blood rises.

How do thiazides cause metabolic alkalosis?

Loop and thiazide diuretics can cause metabolic alkalosis due to increased excretion of chloride in proportion to bicarbonate.

What causes hyperglycemia in non diabetics?

Nondiabetic hyperglycemia usually occurs after the body has undergone some type of trauma or stressful event. It usually resolves when the root of the injury or stressful event improves, but this is not always the case.