How do I get rid of progerin protein?

The buildup of progerin, an abnormal protein, interferes with normal cell functions and can cause early cellular aging. A substance in broccoli called sulforaphane can help break down progerin.

Is progerin lamin A?

Progerin (UniProt# P02545-6) is a truncated version of the lamin A protein involved in the pathology of Hutchinson–Gilford progeria syndrome. Progerin is most often generated by a sporadic single point nucleotide polymorphism c.

What does lamin A protein do?

The lamins are the major architectural proteins of the animal cell nucleus. Lamins line the inside of the nuclear membrane, where they provide a platform for the binding of proteins and chromatin and confer mechanical stability.

How does lamin A cause progeria?

Progeria is caused by a mutation (change) in the lamin A (LMNA) gene. This gene makes a protein that holds the nucleus of a cell together. Because of the change in the gene, the protein becomes defective. This makes the nucleus unstable, which is believed to cause the premature aging process.

How can I reduce progerin naturally?

Naturally, the research team looked for compounds that would enhance the proteasome activity of the cells in order to remove progerin faster. They treated HGPS cells with a compound known as sulforaphane, an antioxidant found in cruciferous vegetables, such as broccoli sprouts.

Does progerin cause aging?

Thus, progerin-dependent mechanisms act in natural aging. Excessive activity of the same mechanisms may well be the cause of premature aging in HGPS. Telomere attrition is widely regarded to be one of the primary hallmarks of aging. Progerin expression in normal human fibroblasts accelerates the loss of telomeres.

How is progerin produced?

Oxidized proteins are degradated in proteasome. Along with age aggregates of oxidized proteins, which cannot be digested are formed. That results in accumulation of lipofuscin which inhibits the action of proteasome of fibroblasts and leads to accumulation of mutant form such as progerin.

What is the difference between lamin A and lamin C?

Lamin A and C are identical for the first 566 amino acids, but lamin C lacks 98 amino acids at the carboxyl terminus that are present in pre-lamin A (before post translational processing) and contains a unique six amino acid carboxyl terminus (Figure ​

What disease causes rapid aging?

Overview. Progeria (pro-JEER-e-uh), also known as Hutchinson-Gilford syndrome, is an extremely rare, progressive genetic disorder that causes children to age rapidly, starting in their first two years of life. Children with progeria generally appear normal at birth.

What is the mutation in lamin A?

A specific mutation in the LMNA gene has been found in most patients with Hutchinson-Gilford progeria syndrome, which is a condition that causes the dramatic, rapid appearance of aging beginning in childhood. This mutation changes a single DNA building block (nucleotide) in the gene.