Does thiazide cause thrombocytopenia?

Does thiazide cause thrombocytopenia?

However, thiazides can also induce severe thrombocytopenia secondary to an immune-mediated mechanism [20]. An accelerated platelet destruction in the presence of the offending drug is most often of immune origin.

Can diuretics cause low platelet count?

Answer. Drugs can induce thrombocytopenia by a number of mechanisms. For example, the cytotoxic drugs can inhibit platelet production in the bone marrow, as can thiazide diuretics, interferon, and alcohol. More commonly, drug-induced thrombocytopenia results from the immunologic destruction of platelets.

Can hydrochlorothiazide cause low platelets?

Kutti and Weinfield found that 26 percent of 71 patients receiving oral diuretics had platelet counts < 100000/ILL1 Thiazide-induced throm- bocytopenic purpura is usually gradual in onset, mild rather than severe, and the decrease in platelet count occurs after several days of therapy.

Which drug Cannot cause impairment of platelet function?

Drug-induced platelet dysfunction is an important cause of an acquired bleeding diathesis….Table II.

Which drug is likely cause of thrombocytopenia?

Heparin, a blood thinner, is the most common cause of drug-induced immune thrombocytopenia.

Can blood pressure medication cause low platelets?

In a case report, doctors found that a low blood pressure medication, amlodipine (a calcium channel blocker with many different names) definitely caused their patient’s low platelets and the cholesterol-lowering drug, simvastatin (Zocor) probably contributed to the low platelets as well.

Which drugs cause low platelet count?

A low platelet count makes bleeding more likely….Other medicines that cause drug-induced thrombocytopenia include:

• Furosemide.
• Gold, used to treat arthritis.
• Nonsteroidal anti-inflammatory drugs (NSAIDs)
• Penicillin.
• Quinidine.
• Quinine.
• Ranitidine.
• Sulfonamides.

Does hydrochlorothiazide affect platelet count?

Results: Both treatments lowered systolic and diastolic blood pressure equally and had no significant effect on platelet counts and platelet aggregation in response to ADP and to arachidonic acid. Haematocrit plasma viscosity and blood filterability were not altered by either drug.

What medication causes low platelets?

Certain medications can reduce the number of platelets in your blood. Sometimes a drug confuses the immune system and causes it to destroy platelets. Examples include heparin, quinine, sulfa-containing antibiotics and anticonvulsants.

Which drug decreases the effectiveness of platelets?

The most commonly used drug that inhibits platelet function is aspirin, which inhibits cyclooxygenase I (COX-1) conversion of arachidonic acid to thromboxane A2, inhibiting platelet function by preventing the enhancement and propagation of agonist-induced platelet signaling.

Which medications cause low platelets?

Causes

• Furosemide.
• Gold, used to treat arthritis.
• Nonsteroidal anti-inflammatory drugs (NSAIDs)
• Penicillin.
• Quinidine.
• Quinine.
• Ranitidine.
• Sulfonamides.

Can Lasix cause thrombocytopenia?

This table lists drugs with evidence for a causal association with isolated thrombocytopenia; certain foods and beverages (eg, quinine-containing beverages, certain herbal teas, walnuts) can also cause thrombocytopenia….