Do bisphosphonates cause dental problems?

The most common complication in patients on bisphosphonate therapy is osteonecrosis of jaw which occurs after any surgical dental procedure. Although, spontaneous cases of osteonecrosis have been reported but in majority of cases (68.8%), patients had a history of dental disease or treatment.

How does bisphosphonates affect dental treatment?

Bisphosphonates irreversibly alter the metabolism of the osteoclasts, so there is little or no bone resorption, even if the blood supply is good. The action of bisphosphonates that dental professionals should be concerned about is that they destroy osteoclasts, without which there is no bone healing.

When are bisphosphonates contraindicated?

Avoid oral bisphosphonates in patients with esophageal disorders such as achalasia, esophageal stricture, esophageal varices, Barrett’s esophagus, inability to stand or sit upright for at least 30 minutes, history of bariatric surgery (Roux-en-Y gastric bypass).

Why do I need to see dentist before bisphosphonates?

Bisphosphonates carry an FDA warning stating that because ONJ has been rarely reported in osteoporosis patients, “all patients should have a routine oral exam prior to treatment.” The risk of ONJ in patients taking bisphosphonate in the doses for osteoporosis is extremely low, estimated to be an incidence of less than …

When can I stop using bisphosphonates before tooth extraction?

If systemic conditions permit, the clinician may consider discontinuation of oral bisphosphonates for a period of three months prior to and three months following elective invasive dental surgery in order to lower the risk of BRONJ.

What are the two main adverse effects of bisphosphonates?

General side effects of bisphosphonates and denosumab

  • Fever and flu-like symptoms.
  • Low levels of calcium in your blood (hypocalcaemia)
  • Bone and joint pain.
  • Changes in bowel movements.
  • Tiredness and low energy levels.
  • Feeling sick.
  • Changes to your kidneys.
  • Irritation of the food pipe (oesophagus)

Do bisphosphonates affect immune system?

This work suggests that bisphosphonates have the potential to depress the innate immune system for a prolonged time, possibly contributing to the pathogenesis of BRONJ.

Why you should not take bisphosphonates?

Rarely, bisphosphonates may cause: Osteonecrosis of the jaw. This bone disease features pain, swelling or infection in the jaw. This occurs most commonly after invasive dental procedures, such as tooth extractions.