Can you get pregnant with Robertsonian translocation?

Male carriers of Robertsonian (ROB) translocation can have infertility and are shown to have abnormal semen analysis. Some patients have positive sperms in the ejaculate. Therefore, fertility management can be offered to couples to achieve pregnancy and delivery of healthy neonates.

Can IVF help with balanced translocation?

IVF-PGD is a treatment option often used for individuals with balanced translocations in an effort to improve the likelihood of achieving a healthy pregnancy 3, 4 while maintaining a genetic link to both parents.

How does Robertsonian translocation affect fertility?

Effect on fertility If you or your partner carry a Robertsonian translocation, you may be at a higher risk for infertility or miscarriage. And when people with this translocation carry a child to term, the child may be at a higher risk for chromosomal imbalance.

Can someone with a balanced translocation have a successful pregnancy?

Natural conception and live birth is possible in cases of balanced translocation, but those with the condition may have more difficulty conceiving and are at a greater risk of recurrent miscarriage than those without it.

Can people with Robertsonian translocation have children?

Many people with Robertsonian translocation have healthy children. The condition can, however, impact on their chances of having a family. Women with the translocation may find it difficult to get pregnant. They also have a higher chance of having a miscarriage than those without Robertsonian translocation.

Is Robertsonian translocation bad?

A person with a Robertsonian translocation has an increased risk of miscarriage for each pregnancy and an increased risk of the baby being born with a disability.

Does balanced translocation cause infertility?

Balanced translocation carriers are burdened with fertility issues due to improper chromosome segregation in gametes, resulting in either implantation failure, miscarriage or birth of a child with chromosomal disorders.

How is Robertsonian translocation detected?

Robertsonian translocation type trisomy 13 can be detected by prenatal diagnosis technology, which inclue molecular cytogenetics and traditional karyotype analysis. Different diagnosis technologies have to be clearly distinguished and correctly applied.

What is the outcome of a Robertsonian translocation?

A Robertsonian translocation results when the long arms of two acrocentric chromosomes fuse at the centromere and the two short arms are lost. If, for example, the long arms of chromosomes 13 and 14 fuse, no significant genetic material is lost—and the person is completely normal in spite of the translocation.

What is the life expectancy of Robertsonian translocation?

Robertsonian translocation does not always cause health problems, and many people will never know they have it. They will usually live as long and healthy a life as their peers, providing there are no other health complications.

How common is Robertsonian translocation?

Robertsonian translocations, fusions between two acrocentric chromosomes, are the most common structural chromosomal rearrangements in humans and occur in approximately 1 in every 1000 newborns [1].

How does Robertsonian translocation occur?