Can pioglitazone cause bladder cancer?

Current evidence suggests that pioglitazone may increase the risk of bladder cancer, possibly in a dose‐ and time‐dependent manner. Patients with long‐term and high‐dose exposure to pioglitazone should be monitored regularly for signs of bladder cancer.

Does pioglitazone lower blood sugar?

Pioglitazone is a diabetes drug (thiazolidinedione-type, also called “glitazones”) used along with a proper diet and exercise program to control high blood sugar in patients with type 2 diabetes. It works by helping to restore your body’s proper response to insulin, thereby lowering your blood sugar.

Is pioglitazone a thiazolidinedione?

There are two thiazolidinediones, rosiglitazone, and pioglitazone, currently approved by the FDA as monotherapy or combined with metformin or sulfonylureas to manage type 2 diabetes mellitus. These medications should be in conjunction with lifestyle modifications such as diet, exercise, and weight reduction.

Does diabetes cause bladder cancer?

Bladder cancer is the sixth most common form of cancer and increased incidences of bladder cancer have been linked with type 2 diabetes.

Can Actos cause kidney damage?

Actos Kidney Disease – Studies have shown that Actos may increase the risk of kidney disease. Kidney disease is already known to be a problem in diabetic patients but when Actos is used, the risk may be four times greater than normal.

Does Actos make you pee a lot?

However, multiple studies have indicated that using high dosages or lengthy courses of Actos and other pioglitazone-containing medications increases the risk. Contact your doctor if you exhibit any of these signs of bladder cancer: Bloody or reddish urine. Frequent urination.

Does pioglitazone cause frequent urination?

This medicine may increase your risk for bladder cancer if you take it for more than 12 months. Tell your doctor right away if you have blood in the urine, a frequent, strong, or increased urge to urinate, painful urination, or pain in the back, lower abdomen, or stomach.

How does pioglitazone cause fluid retention?

An important breakthrough in the field is the finding that the renal collecting duct is a major site for increased fluid reabsorption in response to rosiglitazone or pioglitazone. New evidence also indicates that increased vascular permeability in adipose tissues may contribute to edema formation and body weight gain.

What is the side effects of pioglitazone?

More common

  • Blurred vision or other changes in vision.
  • flushed, dry skin.
  • fruit-like breath odor.
  • headache.
  • increased thirst.
  • increased urination.
  • muscle pain or soreness.
  • problems with your teeth.