Can neutrophils produce IL-17?

Neutrophils have also been identified as a source of IL-17 in human psoriatic lesions (Lin et al., 2011), patients with corneal ulcers caused by filamentous fungi (Karthikeyan et al., 2011), and several mouse models of infectious and autoimmune inflammation (Ferretti et al., 2003, Hoshino et al., 2008, Li et al., 2010) …

Do Th17 cells activate neutrophils?

Whereas Th17 cells are well known to indirectly recruit and activate neutrophils via an IL-17A– and IL-17F–mediated induction of CXCL8, CXCL1, and G-CSF by epithelial and other stromal cells,20 it is currently unclear whether they can directly attract neutrophils.

Do neutrophils produce IL 12?

To the extent that neutrophils produce IL-12 during infection, these cells may also be regarded as crucially important in linking innate and acquired immunity.

Do neutrophils produce IL-8?

These observations may be due to prestimulation, handling and culturing of the granulocytes, or to monocyte contamination. Collectively, our results show that granulocytes have a preformed capacity to produce the cytokine IL-8 and that the production of proinflammatory cytokines by neutrophils is limited to IL-8.

What is the role of IL 17?

Interleukin-17 (IL-17, also known as IL-17A) is a key cytokine that links T cell activation to neutrophil mobilization and activation. As such, IL-17 can mediate protective innate immunity to pathogens or contribute to the pathogenesis of inflammatory diseases, such as psoriasis and rheumatoid arthritis.

What is Th17?

What are T helper 17 (Th17) cells? CD4+ T helper lymphocytes are mediators of cellular immunity that play a critical role in the activation of other immune cells such as B cells and cytotoxic T cells, as well as in the regulation of immune responses.

Do neutrophils produce TNFA?

For example, human neutrophils synthesize – at least in vitro – very low amounts of TNFα (in the order of picogram per milliliter per million cells) in response to TLR agonists (2), which nonetheless exert potent autocrine effects in amplifying neutrophil-derived cytokines and chemokines [(63) and other unpublished …

What is the role of IL 18?

Produced mainly by antigen-presenting cells, IL-18 is a pleiotropic factor involved in the regulation of both innate and acquired immune responses, playing a key role in autoimmune, inflammatory, and infectious diseases.

What is the role of IL-8 in inflammation?

Interleukin-8 (IL-8) is a chemoattractant cytokine produced by a variety of tissue and blood cells. Unlike many other cytokines, it has a distinct target specificity for the neutrophil, with only weak effects on other blood cells. Interleukin-8 attracts and activates neutrophils in inflammatory regions.

What produced IL-17?

IL-17E is produced by many cell types: including epithelial cells, endothelial cells and several immune cells, such as T cells, macrophages, type-2 myeloid cells, DC, eosinophils and ILC2s (109, 110). Table 6. Overview of the role exerted by IL-17E in inflammation.