Can multiple myeloma causes thrombocytopenia?

Multiple myeloma can also cause the level of platelets in the blood to become low (called thrombocytopenia). This can lead to increased bleeding and bruising. Another condition that can develop is leukopenia (a shortage of normal white blood cells).

What is increased in multiple myeloma?

The myeloma cells can cause an overproduction of certain proteins such as Interleukin 6 (IL-6) (also known as osteoclast activating factor or OAF) resulting in activation of osteoclasts which are cells in the body that break down bone.

How do you diagnose multiple myeloma?

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  1. Blood tests. Laboratory analysis of your blood may reveal the M proteins produced by myeloma cells.
  2. Urine tests. Analysis of your urine may show M proteins, which are referred to as Bence Jones proteins when they’re detected in urine.
  3. Examination of your bone marrow.
  4. Imaging tests.

Does multiple myeloma cause purpura?

MM is associated with many haematological, rheumatologic and neurological conditions. A few case reports suggest that MM can be associated with immune thrombocytopenic purpura (ITP), although this is rare.

What are the 3 stages of multiple myeloma?

The stages of myeloma are:

  • Smoldering: Non-active disorder, no symptoms.
  • Stage 1: Early in the disease, no symptoms.
  • Stage 2: The cancer is progressing and causing multiple symptoms.
  • Stage 3: Cancer is in multiple parts of the body and a person will experience complex symptoms.

What are the markers for multiple myeloma?

Myelomatous PCs may express, in addition to CD38 (the most typical PC marker), the antigens CD9, CD10, HLA-DR, and CD20.

Can you have multiple myeloma for years and not know it?

Some people have multiple myeloma for months or years before they even know they’re sick. This earliest phase is called smoldering multiple myeloma. When you have it, you won’t have any symptoms, but your test results will show: At least 10% to 59% of your bone marrow is made up of cancerous plasma cells.