Can cisplatin treat breast cancer?

Cisplatin is FDA approved for other cancers and has been shown to be an active treatment for breast cancer. AZD1775 is a drug that is designed to block a protein called Wee-1 which may control the ability of certain cancer cells to grow or divide….CISPLATIN + AZD-1775 In Breast Cancer.

Masking: None (Open Label)
Primary Purpose: Treatment

What cancers are treated with cisplatin?

Cisplatin, a chemotherapy drug, is best known for curing testicular cancer. It is also used in the treatment of a wide range of other cancers, including lung, bladder, cervical, and ovarian cancers. Cisplatin and other similar platinum-based drugs were developed with National Cancer Institute (NCI) support.

Can cisplatin causes secondary cancer?

Case reports, retrospective analyses, and observational studies have linked the use of cisplatin to increased risk of second cancers, especially life-threatening secondary leukemia.

What is a triple negative breast cancer?

Triple-negative breast cancer is a kind of breast cancer that does not have any of the receptors that are commonly found in breast cancer. Think of cancer cells as a house. The front door may have three kinds of locks, called receptors— One is for the female hormone estrogen.

What are the long term effects of cisplatin?

Cisplatin (CDDP) is a frequently employed chemotherapeutic drug both in curative and palliative settings. When cancer patients are cured due to CDDP therapy, they unfortunately often experience severe long‐term side effects including irreversible hearing loss (ototoxicity) and permanent neuronal and renal damage.

Can breast cancer spread while on chemo?

While chemotherapy is one of the oldest and most successful ways of treating cancer, it doesn’t always work. So, yes, cancer can spread during chemotherapy. Spreading could mean the tumor keeps growing, or that the original tumor shrinks, but cancer metastasizes, forming tumors in other areas of the body.

Why does cancer grow after chemotherapy?

Cancer may sometimes come back after cancer drug treatment or radiotherapy. This can happen because the treatment didn’t destroy all the cancer cells. Chemotherapy drugs kill cancer cells by attacking cells that are in the process of doubling to form 2 new cells.