Can acyclovir be used in pregnancy?

Conclusion: Use of acyclovir in the first trimester does not increase birth defects, and it should be the antiviral drug of choice in early pregnancy.

What category/class is acyclovir?

Acyclovir is in a class of antiviral medications called synthetic nucleoside analogues.

Why is acyclovir contraindicated in pregnancy?

Acyclovir, an antiviral nucleoside analogue, is a widely used agent highly specific for herpes simplex and varicella-zoster viruses. Unintended exposure to acyclovir early in pregnancy, which is not uncommon, may cause excessive maternal and physician anxiety.

Is acyclovir safe during second trimester?

US FDA pregnancy category B: Animal reproduction studies have failed to demonstrate a risk to the fetus and there are no adequate and well-controlled studies in pregnant women. Comments: -This drug has been safely used to treat genital herpes in women in all stages of pregnancy.

Is Zovirax safe in pregnancy?

Cold sores are often treated with aciclovir cream which is a specific antiviral medication. This is applied to the affected area. It is considered safe at all stages of pregnancy.

Is valacyclovir safe in early pregnancy?

This large nationwide historical cohort study found no association between exposure to acyclovir, valacyclovir, or famciclovir in the first trimester of pregnancy and the risk of any major birth defect.

What are contraindications of acyclovir?

The only absolute contraindication to acyclovir is hypersensitivity. Cautions include renal failure/impairment, immunocompromised host, potential risk of thrombotic thrombocytopenic purpura (TTP), and hemolytic uremic syndrome (HUS)).

Is acyclovir 800 mg safe during pregnancy?

Pregnancy and breastfeeding It’s usually safe to use the cream or take aciclovir during pregnancy.

Is acyclovir 400 mg safe during pregnancy?

Suppressive treatment drugs in pregnancy Long-term suppressive therapy can significantly reduce these outbreaks and is likely safe during pregnancy. Acyclovir (Zovirax) and valacyclovir (Valtrex) are the drugs most commonly used for herpes outbreak suppression and treatment during pregnancy.

Is famciclovir safe in pregnancy?