Are CAG repeats located in translated DNA?

CAG repeats within the coding region that are translated into polyglutamine tracts, which lead to protein aggregation and cell death.

What is a CAG repeat?

The HTT mutation that causes Huntington disease involves a DNA segment known as a CAG trinucleotide repeat . This segment is made up of a series of three DNA building blocks (cytosine, adenine, and guanine) that appear multiple times in a row. Normally, the CAG segment is repeated 10 to 35 times within the gene.

How does CAG repeat expand?

CAG, CTG, and CGG repeats form a hairpin. After the hairpin forms, the primer realigns with the 3′ end of the newly synthesized strand and continues the synthesis, leading to triplet repeat expansion.

What causes CAG trinucleotide repeat?

Trinucleotide repeat disorders are caused due to an abnormal number of triplet repeat sequences either in the coding or the non-coding regions and are a result of either maternal or paternal transmission.

Does everyone have CAG repeats?

We all have these CAG repeats in the gene that codes for the huntingtin protein, but people with HD have a greater number than usual of CAG repeats in one of the genes they inherited.

What does CAG mean in Huntington’s?

The faulty version of the gene repeats a particular coding sequence known as CAG (cytosine-adenine-guanine) too many times – a bit like adding too much of one ingredient in a recipe. This means the protein it makes damages nerve cells in the brain.

What does CAG stand for?

For years, the military has delicately referred to this special missions unit (SMU) as “CAG,” which stands for “Combat Applications Group (Airborne).”

What is a CAG count?

The number of CAG repeats in the HD gene determines whether or not someone will develop HD during their lifetime. Everyone has two copies of the HD gene – one from their father and one from their mother.

What does CAG mean in Huntington’s disease?

Some facts about genetics and Juvenile Huntington’s: The faulty version of the gene repeats a particular coding sequence known as CAG (cytosine-adenine-guanine) too many times – a bit like adding too much of one ingredient in a recipe. This means the protein it makes damages nerve cells in the brain.

How many CAG repeats are in Huntington’s?

Normal: 26 or fewer CAG repeats. Intermediate: 27-35 CAG repeats. Not at risk of developing symptoms of HD, but because of instability in the CAG repeats, a person with a CAG number in this range may be at risk of having a child with an expansion of the CAG repeats into the HD-causing range.

How many CAG repeats do normal people have?