What does a positive immunofixation blood test mean?
What does a positive immunofixation blood test mean?
Positive results from the test indicate the presence of abnormal Ig. This may suggest the existence of an underlying health condition, such as: an immune system disorder. multiple myeloma. Waldenstrom’s macroglobulinemia.
What does a normal immunofixation pattern mean?
Immunofixation can either reveal a normal pattern or identify a monoclonal protein or a polyclonal immunoglobulin pattern. A normal result includes a darker immunoglobulin G (IgG) lane, a lighter immunoglobulin A (IgA), an absent immunoglobulin M (IgM), and a denser kappa compared to lambda lane, with ratio of 2:1.
What does immunofixation shows IgG monoclonal protein with lambda light chain?
If a monoclonal protein is identified, its immunoglobulin class (IgG, IgA, IgM, IgD, IgE) and light chain type (kappa, lambda) are determined by immunofixation. If no monoclonal protein is detected, further testing is not warranted….Immunofixation.
| Gammopathy | % @ SLH | % @ Mayo |
|---|---|---|
| IgA | 11 | 11 |
| Light chain | 5 | 5 |
| Biclonal | 5 | 4 |
What is IgG lambda monoclonal gammopathy?
Monoclonal gammopathy of undetermined significance (MGUS) is a condition in which an abnormal protein — known as monoclonal protein or M protein — is in your blood. This abnormal protein is formed within your bone marrow, the soft, blood-producing tissue that fills in the center of most of your bones.
What is lambda light chain myeloma?
Light chain myeloma can be classified as lambda or kappa light chain myeloma, depending on which type the cancerous cells produce. These light chains can build up in the kidneys, nerves, or other organs and cause serious complications. These two types of proteins have different structures.
Which is worse kappa or lambda?
Patients with lambda light chain disease have a three times worse prognosis than kappa light chain disease.
What does high Lambda mean?
A free light chains test measures the amount of lambda and kappa free light chains in the blood. If the amount of free light chains is higher or lower than normal, it can mean you have a disorder of the plasma cells.
