Can you take metformin and repaglinide together?

Adults—The dose should be individualized starting at 1 milligram (mg) repaglinide and 500 mg metformin combination 2 times a day. Your doctor may increase your dose as needed to control your blood sugar up to a maximum of 10 mg repaglinide and 2500 mg metformin combination per day, divided into 2 or 3 doses.

What is the difference between repaglinide and metformin?

Repaglinide causes your pancreas to release more insulin into the blood stream. Metformin reduces the absorption of sugar from the stomach, reduces the release of stored sugar from the liver, and helps your body use sugar better.

How much does repaglinide lower A1C?

Studies examining the use of repaglinide as monotherapy have shown A1C reductions up to 2.3% with fasting and postprandial reductions of 3.9 mmol/L and 6.4 mmol/L respectively.

What are the side effects of repaglinide?

Incidence not known

  • Back, leg, or stomach pains.
  • blistering, peeling, or loosening of the skin.
  • darkened urine.
  • difficulty with breathing.
  • general body swelling.
  • general tiredness and weakness.
  • indigestion.
  • itching or rash.

How long does repaglinide stay in your system?

After single and multiple oral doses in healthy subjects or in patients, peak plasma drug levels (Cmax) occur within 1 hour (Tmax). Repaglinide is rapidly eliminated from the Page 2 – 2 – blood stream with a half-life of approximately 1 hour.

Does repaglinide lower blood sugar?

Repaglinide can cause low blood sugar (hypoglycemia) especially if you are taking other medicines for diabetes. Consuming large quantities of alcohol, not getting enough calories from food, or doing unusually heavy exercise may also lead to low blood sugar.

When is the best time to take repaglinide?

This medicine usually is taken 15 minutes before a meal but may be taken up to 30 minutes before a meal.

Which is better glimepiride or repaglinide?

Conclusion. Repaglinide treatment is more beneficial than glimepiride for decreasing glucose variability in patients with type 2 diabetes. These smaller glucose fluctuations are associated with decreased levels of inflammation and oxidative stress markers.

Does repaglinide make you gain weight?

SIDE EFFECTS: Weight gain, diarrhea, and joint pain may occur. If any of these effects persist or worsen, notify your doctor or pharmacist promptly. Remember that your doctor has prescribed this medication because he or she has judged that the benefit to you is greater than the risk of side effects.

Who should not take repaglinide?

Repaglinide works by causing your pancreas to release more insulin into the blood stream. This medicine does not help patients who have insulin-dependent or type 1 diabetes.

What drug should not be give along with repaglinide and why?

You should not use repaglinide together with gemfibrozil or NPH insulin (such as isophane insulin).

What drugs interact with repaglinide?

Drug interactions of repaglinide. Drugs such as gemfibrozil, clopidogrel, cyclosporine, trimethoprim, macrolide antibiotics, atorvastatin and nifedipine inhibit CYP2C8/CYP3A4 enzymes, and OATP1B1 transporter can increase the plasma concentrations of repaglinide and likelihood of subsequent hypoglycemia.