What is the work of silymarin?

The silymarin exerts membrane-stabilizing and antioxidant activity, it promotes hepatocyte regeneration; furthermore it reduces the inflammatory reaction, and inhibits the fibrogenesis in the liver.

How much silymarin should I take daily?

How much silymarin should I take daily? For dyspepsia and biliary system disorders, daily doses of 12 to 15 g of dried fruit, while an extract containing 200 to 400 mg/day of silymarin is considered effective in various liver disorders.

Does Milkthistle help breast cancer?

Laboratory studies have shown that milk thistle may have cancer-fighting properties. Randomized, controlled human trials are needed to definitively prove its efficacy against breast cancer and other types of cancer. At this time, there’s not enough evidence for or against the use of milk thistle to treat cancer.

What kind of cancer is milk thistle good for?

Milk-thistle compounds have also shown direct anticancer activities in preclinical models, including inducing apoptosis of colon cancer cells, causing cancer cell senescence in a mouse model of breast cancer, and blocking angiogenesis in prostate cancer models.

How fast does silymarin work?

Silymarin from this specific orally administered formulation is rapidly absorbed; the peak plasma concentration of silibinin is reached about 2–4 h after oral administration, and its plasma half-life is approximately 6 h [23].

How long can I take silymarin?

Adult dosage in terms of hepatoprotection is 420 mg/day of extract (standardized to 70-80% silymarin) three times a day for 6-8 weeks. Maintenance dose is 280 mg/day.

Does silymarin cause liver damage?

Clinically, silymarin reduces liver dysfunction, may reduce liver-related mortality in patients with cirrhosis and improves glycemic control in patients with concomitant diabetes, with few if any adverse events.

Is silymarin good for the kidneys?

Recent evidence suggests that silymarin may be just as important for kidney health as for liver. Silymarin concentrates in kidney cells, where it aids in repairing and regeneration by increasing protein and nucleic acid synthesis.

Does Milkthistle block estrogen?

Milk thistle might decrease the effects of medications providing estrogen by blocking how estrogen works in the body.

Does silymarin increase estrogen?

Silymarin is a selective estrogen receptor beta (ERbeta) agonist and has estrogenic effects in the metaphysis of the femur but no or antiestrogenic effects in the uterus of ovariectomized (ovx) rats. J Steroid Biochem Mol Biol. 2003 Aug;86(2):179-88. doi: 10.1016/s0960-0760(03)00270-x.

Can cancer patients take milk thistle?

The U.S. Food and Drug Administration (FDA) has not approved the use of milk thistle as a treatment for cancer or any other medical condition. The FDA does not approve dietary supplements as safe or effective.

Can milk thistle prevent liver cancer?

Although it is possible that milk thistle may play a part in treating liver disease and some types of cancer there is currently not enough evidence for this. We need a lot more research with reliable clinical trials before we can be sure that milk thistle will play any part in treating or preventing cancers.