What is rechallenge chemotherapy?

Chemotherapy rechallenge was defined as the re-use of a drug that had been administered earlier in the course of treatment and stopped due to disease progression or toxicity. At least one line of treatment had to have been received between first use and re-use.

What does rechallenge mean in oncology?

Reintroduction is defined as re-administration of a previous agent to which tumour has not already proved to be resistant and discontinuation was not due to progression of disease (chemotherapy holliday, toxicity, metastasectomy, for example) and rechallenge is the reintroduction exposure of an agent in patients that …

What are the names of chemotherapy drugs?

Types of chemotherapy drugs

  • altretamine.
  • busulfan.
  • carboplatin.
  • carmustine.
  • cisplatin.
  • cyclophosphamide.
  • dacarbazine.
  • ifosfamide.

What is are the goal’s of chemotherapy cancer treatment?

The goals of chemotherapy Sometimes, the goal of treatment is to get rid of all the cancer and keep it from coming back. If this is not possible, you might receive chemotherapy to delay or slow cancer growth. Delaying or slowing cancer growth with chemotherapy also helps manage symptoms caused by the cancer.

What is Dechallenge and rechallenge positive and negative?

A dechallenge is positive when after removal of the drug the adverse event subsides or disappears. A dechallenge is negative when the event persists even after removal of the drug i.e. a causal relationship is unlikely. Rechallenge. The point at which a drug is given again to a patient after its previous withdrawal.

Is rechallenge a word?

noun. 1A challenge made in return; a second or repeated challenge. The action of rechallenge ; an instance of this.

What is the strongest chemo drug?

Doxorubicin (Adriamycin) is one of the most powerful chemotherapy drugs ever invented. It can kill cancer cells at every point in their life cycle, and it’s used to treat a wide variety of cancers. Unfortunately, the drug can also damage heart cells, so a patient can’t take it indefinitely.

What is the next treatment after chemotherapy?

Adding a new drug that works in a different way can continue to shrink the cancer after the initial treatment. This approach is sometimes called “switch maintenance.” Usually this involves switching from chemotherapy to another type of treatment, such as immunotherapy or targeted therapy.

What Dechallenge means?

Dechallenge is a response observed for the reduction or disappearance of adverse drug reactions (ADR) on withdrawal of a drug from a patient.

What is a Dechallenge rechallenge strategy?

Challenge–dechallenge–rechallenge (CDR) is a medical testing protocol in which a medicine or drug is administered, withdrawn, then re-administered, while being monitored for adverse effects at each stage.

What does challenge mean in medicine?

[chal´enj] 1. to administer a chemical substance to a patient for observation of whether the normal physiological response occurs. 2. in immunology, to administer antigen to evoke an immunologic response in a previously sensitized individual.