What is a second-site suppressor mutation?

What is a second-site suppressor mutation?

Identifying rescue mutations, often referred to as second-site suppressor mutations, controls against scenarios in which the initial deleterious mutation inactivates the protein or disrupts alternative protein-protein interactions.

What is second-site mutation?

The second mutation of a double mutation within a gene. In many cases, the second-site mutation suppresses the first mutation, so that the double mutant has the wild-type phenotype. Tags: Molecular Biology.

What is intragenic and intergenic mutation?

Intragenic suppressor mutation refers to a second mutation within the same gene, which restores the function of the mutant gene product while intergenic suppressor mutation refers to a second mutation which relieves the effects of a mutation in one gene by a mutation somewhere else within the genome.

What does a suppressor mutation suppress?

Suppressor mutations. A mutation in the gene for a tRNA molecule that changes its anticodon loop can “suppress” nonsense mutations that occur elsewhere in protein-coding genes. because UAG is a ‘stop’ codon (the so-called amber stop).

What type of mutation is a suppressor mutation?

A suppressor mutation is a second mutation that alleviates or reverts the phenotypic effects of an already existing mutation in a process defined synthetic rescue. Genetic suppression therefore restores the phenotype seen prior to the original background mutation.

What is Intragenic suppression?

Intragenic suppressors are second mutations within the same gene that restore function of the mutant gene product.

What is intergenic suppressor mutation?

Intergenic suppression Intergenic (also known as extragenic) suppression relieves the effects of a mutation in one gene by a mutation somewhere else within the genome. The second mutation is not on the same gene as the original mutation.

What is the difference between an intragenic and intergenic suppressor?

A suppressor is a second mutation that restores a function lost by the primary mutation. A suppressor mutation that occurs within the same gene is called an “intragenic suppressor”, and a suppressor mutation that occurs in a different gene is called an “intergenic suppressor”.

What is a suppressor in biology?

In genetics, a silencer is a DNA sequence capable of binding transcription regulation factors, called repressors. DNA contains genes and provides the template to produce messenger RNA (mRNA). That mRNA is then translated into proteins.

What’s another word for suppressor?

What is another word for suppressor?