Can you be allergic to succinylcholine?

There have been post-marketing reports of severe allergic reactions (anaphylactic and anaphylactoid reactions) associated with use of neuromuscular blocking agents, including ANECTINE (succinylcholine chloride) . These reactions, in some cases, have been life-threatening and fatal.

Does succinylcholine cause anaphylaxis?

Despite its unique properties (i.e. short onset and offset and intense blockade), succinylcholine may induce some severe adverse reactions, such as anaphylactic reactions. Diagnosing anaphylactic reactions remains challenging.

Who are the patients who should not be given succinylcholine Why?

The administration of succinylcholine chloride is contraindicated in patients with known decreased plasma cholinesterase activity, recent burns or trauma within 24 to 72 hours, and muscle myopathies.

How do you test for succinylcholine allergy?

Pseudocholinesterase deficiency may be suspected when you have problems recovering muscle control and breathing after you get the muscle relaxant succinylcholine as part of anesthesia. A blood test can tell if you have enough of the pseudocholinesterase enzyme.

What is succinylcholine allergy?

Overview. Pseudocholinesterase (soo-doe-koh-lin-ES-tur-ays) deficiency is a rare disorder that makes you sensitive to certain muscle relaxants ― succinylcholine or mivacurium ― used during general anesthesia.

What class is succinylcholine?

Anectine belongs to a class of drugs called Neuromuscular Blockers, Depolarizing.

What is a possible complication associated with succinylcholine administration?

However succinylcholine is associated with severe hyperkalaemia, arrhythmia and cardiac arrest especially in severe burn and neuromuscular disease and renal failure.

Does succinylcholine cause histamine release?

Furthermore, succinylcholine increases plasma noradrenaline (norepinephrine) concentrations, resulting in cardiovascular effects. Finally, the histamine-releasing properties of muscle relaxants are well known, and succinylcholine has the strongest histamine-releasing effect of all such agents.

What is antidote for succinylcholine?

Dantrolene is an effective antidote.

Is there an antidote for succinylcholine?

Is succinylcholine still used in anesthesia?

Infusions of succinylcholine in particular are an outdated anesthesia technique that should no longer be employed because of the risk of bradycardia and prolonged duration of neuromuscular block.

Which drugs cause histamine release?

Histamine release is primarily caused by morphine, followed by hydromorphone, and is least likely to occur with fentanyl. Other commonly used sedatives, such as propofol and benzodiazepines, have a direct vasodilatory effect.