What are myelin figures in cell injury?

Dead cells may be replaced by large, whorled phospholipid masses called myelin figures that are derived from damaged cell membranes.

What are myelin figures in necrosis?

Dead cells may ultimately be replaced by large, whorled phospholipid masses called myelin figures. These phospholipid precipitates are then either phagocytosed by other cells or further degraded into fatty acids; calcification of such fatty acid residues results in the generation of calcium soaps.

What is the hallmark of irreversible cell injury?

Irreversible cell injury: mitochondria swell, lysosomes swell, damage to plasma membrane and lysosomal membranes leads to enzyme leakage; acidosis somewhat protective by inhibiting enzymatic reactions.

Are myelin figures are reversible or irreversible?

Solution: Myelin figures are concentric whorls of membranes derived from damaged cell membranes. It is seen in both reversible and irreversible injury.

Why myelin figures are formed?

Membranous whorls derived from the rough endoplasmic reticulum became partly electron dense, forming myelin figures. The apposing membranes of the smooth endoplasmic reticulum were closely approximated or fused with each other to connect with the peripheral lamellae of myelin figures.

Is Karyolysis reversible?

It is an irreversible condition of chromatin in the nucleus of a cell wall undergoing necrosis or apoptosis. 2. Karyorrhexis is the destructive fragmentation of the nucleus of a daily cell whereby its chromatin is distributed irregularly throughout the cytoplasm. 3.

What are the two types of cell injury?

Types of cell injury: Reversible injury. Irreversible injury Irreversible Injury Ischemic Cell Damage (leads to cell death)

What is the single most common cause of cellular injury?

Hypoxia is the most important cause of cell injury. Irreversible cell injury can be recognized by changes in the appearance of the nucleus and rupture of the cell membrane.

What happens when the myelin sheath is damaged?

A demyelinating disease is any condition that results in damage to the protective covering (myelin sheath) that surrounds nerve fibers in your brain, optic nerves and spinal cord. When the myelin sheath is damaged, nerve impulses slow or even stop, causing neurological problems.

Can myelin sheath be repaired?

Myelin is repaired or replaced by special cells in the brain called oligodendrocytes. These cells are made from a type of stem cell found in the brain, called oligodendrocyte precursor cells (OPCs). And then the damage can be repaired.

What causes karyolysis?

Karyolysis: This change results from the lysis of chromatin due to the action of endonucleases.

What is the most common cause of cell injury?