What is Chlorobutanol used for?
What is Chlorobutanol used for?
Chlorobutanol is a common detergent preservative in eye drops and other ophthalmic therapeutic formulations. Chlorobutanol is a tertiary alcohol. A colorless to white crystalline compound with a camphoraceous odor and taste. It is a widely used preservative in various pharmaceutical solutions, especially injectables.
What is Chlorobutanol Hemihydrate?
Name Chlorobutanol hemihydrate Drug Entry Chlorobutanol. Chlorobutanol, or chlorbutol, is an alcohol-based preservative with no surfactant activity 5. It also elicits sedative-hypnotic and weak local anesthetic actions in addition to antibacterial and antifungal properties.
What catalyst is used in Chlorobutanol?
Chlorobutanol (1) is prepared by addition of chloroform to acetone under the catalytic influence of powdered potassium hydroxide 1. I1/ has a local anesthetic potency to a mild degree and is used as an anesthetic dusting powder.
Which solvent is used for recrystallization of Chlorobutanol?
So it must be recrystallized from water/alcohol mixture. Water is not good solvent for recrystallization and often hydroalcoholic mixtures are used for this purpose. Preparation of chlorobutanol: It is prepared from acetone and chloroform using KOH to give chlorobutanol.
What is the reaction involved in chlorobutanol?
Similar in nature to chloral hydrate, it is formed by the simple nucleophilic addition of chloroform and acetone. As a long-term stabilizer of multi-ingredient preparations, chlorobutanol is normally used at a concentration of 0.5%. At this concentration, it also conserves its antimicrobial activity.
Is chlorobutanol basic or acidic?
Acid dissociation constants calculated using MoKa v3.0.0
| Dissociation level | Dissociation constant | Type (acidic/basic) |
|---|---|---|
| pKa1 | 13.69 | acidic |
What is the theory of chlorobutanol?
Chlorobutanol (trichloro-2-methyl-2-propanol) is a preservative, sedative, hypnotic and weak local anesthetic similar in nature to chloral hydrate. It has antibacterial and antifungal properties.
What is the melting point of chlorobutanol?
A crystal of chlorobutanol placed on a water surface “dances” like a camphor crystal. Sublimes easily. The anhydrous form mp 97° (the hemihydrate mp 78°).
What is the structure of chlorobutanol?
C4H7Cl3OChlorobutanol / Formula
Is Chlorbutol and chlorobutanol the same?
Chlorobutanol, or chlorbutol, is an alcohol-based preservative with no surfactant activity 5. It also elicits sedative-hypnotic and weak local anesthetic actions in addition to antibacterial and antifungal properties.
