What is serum EPO?

An EPO Test is a blood disorder serum test used to determine erythropoietin level, an important hormone produced by the kidneys that is critical for the formation of red blood cells by the bone marrow.

What causes low EPO levels?

The production of erythropoietin is reduced in certain conditions such as kidney failure, chronic diseases like HIV/AIDS, and certain cancers and in chronic inflammatory diseases like rheumatoid arthritis.

What causes elevated erythropoietin levels?

EPO levels are also increased in patients with anemia of bone marrow failure, iron deficiency, or thalassemia. Patients, who have either a poor or no erythropoietic response to EPO therapy, but high-normal or high EPO levels, may have additional, unrecognized causes for their anemia.

What if EPO is low?

If the levels are too low, that can mean EPI is keeping your body from absorbing these nutrients. The lab might also look for a chemical your pancreas makes to help with digestion called trypsinogen. A level that’s too high is a sign of a problem.

Is EPO high in iron deficiency anemia?

Conclusion: The serum EPO is involved in the process of erythrocyte hematopoiesis, and can indicate the level of anemia, its sensitivity for anemia is higher than that of ferritin, and has important clinical value for evaluating status of diseases, observing therapeutic efficacy and judging prognosisi of IDA.

What does it mean if erythropoietin is high?

Having higher levels of erythropoietin in the blood may be a sign that the body is not getting enough oxygen, however. This may be due to a low red blood cell count from anemia or another condition. On the other hand, low levels of erythropoietin in the blood in someone with anemia may be a sign of other issues.

How does EPO affect blood pressure?

Brief Summary: The investigators hypothesize that compared to untreated controls, erythropoietin (EPO) therapy in anemic patients with chronic kidney disease will raise diastolic blood pressure (BP). The magnitude of increase in diastolic BP at 12 weeks after treatment will be related to two factors.

Does EPO increase in iron deficiency anemia?

(3) The level of serum EPO in patients of severe anemia group was obviously higher than that in patients of moderate and mild anemia groups, and along with aggravation of anemia, the EPO level was gradually arised.

What organ is responsible for erythropoietin?

Erythropoietin (EPO) is produced by the kidney and used to make red blood cells.

Does EPO increase ferritin?

We observed higher ferritin levels in lymphoma patients with high EPO levels compared to healthy controls (P<0.001), that has been explained by erythropoietic response to anemia. Therefore, the ferritin level may indicate the increase of EPO activity among lymphoma patients.

What vitamins are needed for erythropoiesis?

Folate, vitamin B12, and iron have crucial roles in erythropoiesis. Erythroblasts require folate and vitamin B12 for proliferation during their differentiation.

What happens if you have too many red blood cells?

The increase in blood cells makes the blood thicker. Thick blood can lead to strokes or tissue and organ damage. Symptoms include lack of energy (fatigue) or weakness, headaches, dizziness, shortness of breath, visual disturbances, nose bleeds, bleeding gums, heavy menstrual periods, and bruising.