What is Perforant pathway?

The perforant pathway is a large neuronal projection that arises from layers II and III of the entorhinal cortex of the parahippocampal gyrus. It is the principal source of cortical input to the hippocampal formation.

Why is it called the perforant path?

In rats. In rats, pyramidal and stellate cells in layer II of entorhinal cortex project through the subiculum of the hippocampus, giving rise to the name “perforant pathway”.

Can my child live a normal life with seizures?

Many children outgrow their seizures. A child is more likely to outgrow his seizures if he has a normal EEG, normal MRI, normal development, no other neurological problems, and the seizures are controlled easily with medication.

What does the Papez circuit do?

The Papez circuit /peɪpz/, or medial limbic circuit, is a neural circuit for the control of emotional expression. In 1937, James Papez proposed that the circuit connecting the hypothalamus to the limbic lobe was the basis for emotional experiences.

What does the entorhinal cortex do?

The entorhinal cortex is the gateway for information entering and leaving the hippocampal formation. The entorhinal cortex is a component of the medial temporal lobe memory system, although it is increasingly believed to have a perceptual function (Baxter, 2009; Suzuki, 2009).

How long does LTP last in a brain slice?

I-LTP lasts about 30–60 min and does not require protein kinase activity (Roberson et al., 1996).

What do neural pathways do?

A neural pathway is the connection formed by axons that project from neurons to make synapses onto neurons in another location, to enable a signal to be sent from one region of the nervous system to another. Neurons are connected by a single axon, or by a bundle of axons known as a nerve tract, or fasciculus.

Can child epilepsy grow out?

Epilepsy can begin at any time of life, but it’s most commonly diagnosed in children, and people over the age of 65. Some children with epilepsy will outgrow their seizures as they mature, while others may have seizures that continue into adulthood.