What is recombinant granulocyte-macrophage colony-stimulating factor?

Recombinant granulocyte colony stimulating factor (G-CSF) and granulocyte-macrophage colony stimulating factor (GM-CSF) can be used to stimulate neutrophil and, in the case of GM-CSF, monocyte production and mobilization from the bone marrow.

What is granulocyte colony stimulating factor used for?

Granulocyte colony-stimulating factor is used in patients who have certain cancers and neutropenia caused by some types of chemotherapy and in patients who have severe chronic neutropenia that is not caused by cancer treatment. It is also used before an autologous stem cell transplant.

What is G-CSF?

G-CSF helps the bone marrow make more white blood cells. It is a type of colony-stimulating factor. Also called filgrastim and granulocyte colony-stimulating factor.

How does a colony stimulating factors work?

Colony-stimulating factors (CSFs) are secreted glycoproteins that bind to receptor proteins on the surfaces of hematopoietic stem cells, thereby activating intracellular signaling pathways that can cause the cells to proliferate and differentiate into a specific kind of blood cell, usually white blood cells.

When do you give G-CSF?

Patients should receive GCSF from day five until bone marrow recovery. Doses should be rounded to the nearest vial or pre-filled syringe size. G-CSF should not be administered within 24 hours of cytotoxic chemotherapy. The recommended start date is 3 days after the administration of chemotherapy.

Where do you inject G-CSF?

You usually have injections under the skin (subcutaneous injection) into the stomach, thigh or top of your arm. You might have stinging or a dull ache for a short time after this type of injection but they don’t usually hurt much. The skin in the area may go red and itchy for a while.

Is colony stimulating factor a protein?

Colony stimulating factors (CSFs) are proteins that stimulate production of immune (white blood) cells and provide life-saving protection against infection.

What does GM-CSF stimulate?

Granulocyte macrophage colony-stimulating factor (GM-CSF) is a cytokine that promotes myeloid cell development and maturation, and dendritic cell differentiation and survival in vitro.

What is recombinant granulocyte colony stimulating factor (RG-CSF)?

Recombinant granulocyte colony-stimulating factor (rG-CSF) is a glycoprotein hormone which has been produced in mammalian cells and, in a nonglycosylated form, in the bacterium Escherichia coli through recombinant DNA technology. It stimulates proliferation, differentiation and activation of cells o …

What is Mouse granulocyte-colony stimulating factor (G-CSF)?

Mouse granulocyte-colony stimulating factor (G-CSF) was first recognised and purified in Walter and Eliza Hall Institute, Australia in 1983, and the human form was cloned by groups from Japan and Germany/United States in 1986.

What is the CID for granulocyte-colony stimulating factor (GCSF)?

S2CID 26877622. Kanda N, Fukushige S, Murotsu T, Yoshida MC, Tsuchiya M, Asano S, Kaziro Y, Nagata S (November 1987). “Human gene coding for granulocyte-colony stimulating factor is assigned to the q21-q22 region of chromosome 17”.

What does granulocyte colony stimulating factor do for Alzheimer’s disease?

“Granulocyte colony stimulating factor decreases brain amyloid burden and reverses cognitive impairment in Alzheimer’s mice”. Neuroscience. 163 (1): 55–72. doi: 10.1016/j.neuroscience.2009.05.071.