What is intestinal type of gastric carcinoma?

Gastric cancer consists of two pathological variants, intestinal and diffuse. The intestinal-type is the end-result of an inflammatory process that progresses from chronic gastritis to atrophic gastritis and finally to intestinal metaplasia and dysplasia.

WHO histological classification of gastric cancer?

The 2010 WHO classification recognizes four major histologic patterns of gastric cancers: tubular, papillary, mucinous and poorly cohesive (including signet ring cell carcinoma), plus uncommon histologic variants (24).

What are the types of gastric adenocarcinoma?

There are 2 main types of stomach adenocarcinomas: The intestinal type tends to have a slightly better prognosis (outlook). The cancer cells are more likely to have certain gene changes that might allow for treatment with targeted drug therapy. The diffuse type tends to grow spread more quickly.

What is the Lauren classification?

According to Lauren’s criteria, gastric cancer is classified into two main types: Intestinal and diffuse type (5). Intestinal and diffuse gastric cancer exhibit numerous differences in pathology, epidemiology and etiology (5,6).

What is adenocarcinoma diffuse type?

Diffuse type gastric adenocarcinoma – carcinoma composed of poorly differentiated / signet ring cells, present as scattered individual cells or clusters. This type of carcinoma is associated with aggressive behavior (rapid invasion, chemoresistance, peritoneal metastasis) and poor prognosis.

What is Borrmann classification?

The most commonly used classification method for gastric cancer is Borrmann classification, which is mainly based on the appearance and growth state of the tumor. Based on the the Borrmann criteria, which has satisfactory results according to the clinical statistics, GCs are divided into four groups.

What is signet ring cell?

In histology, a signet ring cell is a cell with a large vacuole. The malignant type is seen predominantly in carcinomas.

What causes gastric carcinoma?

Though the actual cause of stomach cancer is not yet known, there are some factors associated with it, particularly diet and lifestyle. For example, a diet high in smoked or salted foods and processed meat and low in vegetables is a risk factor for stomach cancer, as is drinking alcohol and smoking.

What are the most frequent symptoms of gastric carcinoma?

Symptoms

  • Feeling bloated after eating.
  • Feeling full after eating small amounts of food.
  • Heartburn.
  • Indigestion.
  • Nausea.
  • Stomach pain.
  • Unintentional weight loss.
  • Vomiting.