What drug is used in the treatment of extravasation with dobutamine?

Since the vasoconstriction is due to alpha1-adrenergic agonism, phentolamine works as a direct antidote to extravasation by blocking alpha1 receptors.

When is phentolamine used for extravasation?

You’ll want to give the phentolamine as soon as possible, although it may be effective as long as 12 hours after the extravasation.

What is the very first thing you should do if you suspect a drug extravasation?

When an extravasation occurs or is suspected, the first action to take is to stop the infusion (AII). Leave the cannula in position and attempt to aspirate as much of the vesicant as possible from the device; if an antidote is available, an appropriate amount should be instillated through the existing i.v. (AIII).

How do you inject phentolamine for extravasation?

Phentolamine (Regitine)2,5 Prepare by diluting 5 mg phentolamine in 10 mL of 0.9% sodium chloride. Inject subcutaneously into the extravasation area within 12 hours of extravasation. Blanching should reverse immediately; additional injections may be required if blanching returns.

How does hyaluronidase work in extravasation?

Hyaluronidase degrades glycosaminoglycans and hyaluronic acid, with subsequent increases in tissue permeability and dispersion of extravasated agent. Hyaluronidase has been used for extravasation by etoposide, taxanes (ie, paclitaxel, docetaxel, and cabazitaxel), and vinca alkaloids.

Why does dopamine cause extravasation?

Significant local tissue injury was observed in both patients. Discussion: Dopamine infusion can cause tissue ischemia or necrosis secondary to vasospasm and extravasation. Most of the case reports in the literature have occurred when relatively high doses of dopamine were infused.

Can you give dopamine through a peripheral IV?

Norepinephrine, dopamine, and phenylephrine were all approved for use through peripheral intravenous access.

What is the nurse’s priority action if extravasation of an antineoplastic drug occurs?

When an extravasation occurs or is suspected, the first action to take is to stop the infusion (AII).