What is the most common adverse reaction to IV vancomycin?

The most common adverse reaction to vancomycin is “vancomycin infusion reaction (VIR),” previously known as “red man syndrome,” although we will avoid further use of this term for the reasons outlined previously.

Which of the following is a side effect of daptomycin?

Nausea, vomiting, constipation, diarrhea, headache, dizziness, trouble sleeping, increased sweating, or pain/redness/swelling at the injection site may occur. If any of these effects last or get worse, tell your doctor or pharmacist promptly.

What is the most serious side effect of vancomycin?

This medicine may cause serious skin reactions, including toxic epidermal necrolysis, Stevens-Johnson syndrome, drug reaction with eosinophilia and systemic symptoms (DRESS), acute generalized exanthematous pustulosis (AGEP), and linear IgA bullous dermatosis (LABD).

What is the difference between daptomycin and vancomycin?

Vancomycin is the standard first-line treatment for methicillin-resistant Staphylococcus aureus bacteremia. However, recent consensus guidelines recommend that clinicians consider using alternative agents such as daptomycin when the vancomycin minimum inhibitory concentration is greater than 1 ug/ml.

How does vancomycin make you feel?

Nausea, abdominal pain, vomiting, diarrhea, flatulence, and low potassium levels are the most common side effects associated with vancomycin capsules. Edema, back pain, urinary tract infection, and a headache may also occur.

Does IV vancomycin make you tired?

Vancomycin can cause kidney damage. If you experience symptoms of reduced kidney function such as decreased urine production, swelling, fatigue, abdominal pain, let your doctor know as soon as possible.

What should I monitor while on daptomycin?

Patients should also receive monitoring for muscle pain or weakness, new-onset or worsening peripheral neuropathy, and signs or symptoms of eosinophilic pneumonia. [14][18] Furthermore, patients who develop diarrhea should have testing for C. difficile infection.

What should I monitor when on daptomycin?

Patients receiving daptomycin should be monitored for the development of muscle pain or weakness. Consideration should be given to temporarily suspending agents associated with rhabdomyolysis.

Can you take daptomycin if allergic to vancomycin?

Daptomycin is indicated for: treatment of resistant gram-positive infection (e.g., MRSA or VRE) in patients who are allergic to vancomycin (Vancocin, Lilly) or linezolid (Zyvox, Pfizer). treatment of resistant gram-positive infection (e.g., MRSA or VRE) that is resistant to vancomycin and linezolid.

Is vancomycin cheaper than daptomycin?

Results: Total treatment costs in the base-case were lower for linezolid ($10,571) than vancomycin ($11,096), and daptomycin ($13,612). Inpatient treatment costs were $740 more, but outpatient costs, $1,266 less with linezolid than vancomycin therapy due to a switch to oral linezolid when the patient was discharged.

Why is vancomycin last resort?

Vancomycin has long been considered a drug of last resort, due to its efficiency in treating multiple drug-resistant infectious agents and the requirement for intravenous administration. Recently, resistance to even vancomycin has been shown in some strains of S. aureus (sometimes referred to as vancomycin resistant S.

What should I monitor with vancomycin?

Vancomycin Monitoring

  • Vancomycin serum concentrations should be checked to optimize therapy and used as a surrogate marker of effectiveness.
  • Trough, rather than peak, levels should be monitored.
  • Trough levels should be checked just before the fourth dose, when steady-state levels are likely to have been achieved.