What are quinazoline derivatives?

The quinazoline derivative CEP-32496 is a novel, orally active BRAF inhibitor identified to be highly effective against the proliferation of multiple BRAF(V600E)-dependent cancer cell lines and BRAF(V600E)-dependent xenograft mouse models of human colorectal cancer [82, 83].

Which drug consist quinazolinone ring?

Quinazoline and quinazolinone-based drugs. Several quinazolinone-based drugs including idelalisib and fenquizone have been shown to exhibit a broad spectrum of antimicrobial, antitumor, antifungal, and cytotoxic activities [20]. Lapatinib has been displayed to be effective in combination therapy for breast cancer [21].

What is quinazoline used for?

One of the most important heterocycles in medicinal chemistry are quinazolines possessing wide spectrum of biological properties like antibacterial, antifungal, anticonvulsant, anti-inflammatory, anti-HIV, anticancer and analgesic activities.

Who discovered quinazoline?

The synthesis of quinazoline was first reported in 1895 by August Bischler and Lang through the decarboxylation of the 2-carboxy derivative (quinazoline-2-carboxylic acid).

What is pteridine ring explain?

[ tĕr′ĭ-dēn′ ] Any of a group of organic compounds having two fused six-member rings each containing two nitrogen atoms and four carbon atoms. One of the rings is a pyrimidine, the other a pyrazine. Pteridines include folic acid and the pigments of butterfly wings.

What is thiazole ring?

Thiazoles are structurally similar to imidazoles, with the thiazole sulfur replaced by nitrogen. Thiazole rings are planar and aromatic. Thiazoles are characterized by larger pi-electron delocalization than the corresponding oxazoles and have therefore greater aromaticity.

Which drug contains Quinazoline alkaloids?

The pharmacologically important tryptanthrine, a quinazoline alkaloid, is known for its antimycotic activity and is used against skin infections. This alkaloid is obtained from isatin (260) and o-azidobenzoyl chloride (261), as shown in Scheme 96.

What is quinoline ring?

quinoline, any of a class of organic compounds of the aromatic heterocyclic series characterized by a double-ring structure composed of a benzene and a pyridine ring fused at two adjacent carbon atoms. The benzene ring contains six carbon atoms, while the pyridine ring contains five carbon atoms and a nitrogen atom.

What is Pteridine derivative?

Introduction. Triamterene, a pteridine derivative, is a diuretic that acts by inhibiting sodium reabsorption in the late distal tubule and collecting ducts.