What is Lp-PLA2 level?

Purpose: Lipoprotein-associated phospholipase A2 (Lp-PLA2) is an inflammatory biomarker secreted in the atherosclerotic plaque. Blood levels of Lp-PLA2 predict future cardiovascular events in patients with ischemic disease and heart failure.

What does Lp-PLA2 test for?

The Lp-PLA2 test is sometimes used to help evaluate a person’s risk of developing coronary heart disease (CHD) or to help determine the risk of having an ischemic stroke. Lp-PLA2 is an enzyme that appears to play a role in the inflammation of blood vessels and is thought to help promote atherosclerosis.

Is LP A the same as Lp-PLA2?

In addition to LDL, and HDL, another carrier of Lp-PLA2 in plasma is Lp(a) (enriched in Lp-PLA2 compared with LDL). However, Lp(a) can influence the distribution of Lp-PLA2 between LDL and HDL in plasma (17).

What causes high Lp-PLA2?

When disease is active in the artery, increased levels of Lp-PLA2 are produced by macrophages and foam cells within the intima of the artery1. Lp-PLA2 also interacts with oxidized LDL, which increases inflammation and enhances a proatherogenic state, as well as plaque vulnerability2.

How do you reduce PLA2?

Statins appear to significantly lower Lp-PLA2 levels; fibrates and niacin may also lower Lp-PLA2 levels, though this is less well established. Darapladib, a potent, selective Lp-PLA2 inhibitor, is currently in phase III trials for prevention of recurrent vascular events in patients with coronary artery disease.

Can a blood test tell if you have heart disease?

Troponin T is a protein found in heart muscle. Measuring troponin T using a high-sensitivity troponin T test helps health care providers diagnose a heart attack and determine the risk of heart disease. An increased level of troponin T has been linked with a higher risk of heart disease in people who have no symptoms.

How do you test for lipoprotein A?

The lipoprotein (a) test is just like any other blood test. A blood sample will be taken from your arm and sent to a lab for analysis. Your doctor will review the test results and talk to you about them. The normal range of lipoprotein (a) is 30 milligrams or less per deciliter.

What is small LDL P in blood test?

Your Small LDL-P number is a measure of the number of small LDL particles in your blood. These particles are associated with an increased risk of heart disease; more of these small particles lead to greater risk. Your Small LDL particle score can vary widely, with a lower score being much better.

How do you reduce Lp-PLA2 levels?

There are a number of things you can do to lower your overall risk of heart disease, as well as lowering your Lp-PLA2 Activity levels. Adopt a heart-healthy diet by eating more vegetables, fruits, and whole grain foods and reducing the amount of fatty foods you eat. Exercise more and on a consistent basis.

How can I reduce lipoprotein naturally?

Oatmeal, oat bran and high-fiber foods Oatmeal contains soluble fiber, which reduces your low-density lipoprotein (LDL) cholesterol, the “bad” cholesterol. Soluble fiber is also found in such foods as kidney beans, Brussels sprouts, apples and pears.

What is PLA disease?

Primary lateral sclerosis (PLS) is a type of motor neuron disease that causes the nerve cells in the brain that control movement to fail over time. PLS causes weakness in your voluntary muscles, such as those you use to control your legs, arms and tongue.