How common is APL leukemia?

APL comprises 5 to 10% of all cases of adult acute myeloid leukemia. Each year in the United States, it develops in around 2.2 people per million, for a total of 600 to 800 individuals. Although APL can occur at any age, middle age adults are most commonly affected; the median age at diagnosis is around 40.

What is the survival rate for APL leukemia?

APL is now considered a highly curable disease, with 2-year event-free survival rates of 75–84%. Early mortality is common in APL and is frequently related to hemorrhagic complications. Prior to ATRA therapy, early death (ED) related to hemorrhage occurred in up to 26% of cases.

How often does APL relapse?

However, for patients treated with ATRA plus anthracycline chemotherapy, relapse occurs in 5 to 10 percent of patients with APL and in 20 to 30 percent of those with high-risk APL (ie, presentation with a white blood cell count >10,000/microL and a platelet count <40,000/microL).

How common is APL in children?

Acute promyelocytic leukemia (APL) is a rare disease accounting for only 5%–10% of pediatric acute myeloid leukemia (AML) and fewer than 1000 cases occur annually in the United States across all age groups.

Is APL leukemia rare?

APL is a relatively rare type of leukemia that causes a buildup of immature white blood cells in your blood and bone marrow.

Is acute promyelocytic leukemia common?

Acute promyelocytic leukemia accounts for about 10 percent of acute myeloid leukemia cases. Acute promyelocytic leukemia occurs in approximately 1 in 250,000 people in the United States.

How curable is APL leukemia?

Because of advances in diagnostic techniques and modern treatments, APL is today considered to be the most curable subtype of acute myeloid leukemia in adults, with complete remission rates of 90 percent and cure rates of approximately 80 percent and even higher among low-risk patients.

Can you survive acute promyelocytic leukemia?

Unlike most leukemias, acute promyelocytic leukemia (APL) has a very good prognosis, with long-term survival rates up to 90% following treatment.

Can APL be cured as of 2021?

Because of advances in diagnostic techniques and modern treatments, APL is now considered the most curable subtype of AML in adults, with complete remission rates of 90 percent following treatment and cure rates of approximately 80 percent reported in clinical trials.

Does APL come back?

Acute promyelocytic leukaemia (APL) treatment If you do go into remission, but the cancer comes back, this is known as a relapse. This is especially rare if you were treated with ATRA and arsenic trioxide.

Is acute promyelocytic leukemia rare?

Acute promyelocytic leukaemia (APML) is a rare sub-type of acute myeloid leukaemia (AML) and is sometimes referred to as AML M31. APML accounts for only 10% of all AML diagnoses. In APML, immature abnormal neutrophils (a type of white blood cell) known as promyelocytes accumulate in the bone marrow.

Can APL leukemia be cured?