Which heterocyclic ring is present in furosemide?

Furosemide is a chlorobenzoic acid that is 4-chlorobenzoic acid substituted by a (furan-2-ylmethyl)amino and a sulfamoyl group at position 2 and 5 respectively. It is a diuretic used in the treatment of congestive heart failure.

How is furosemide absorbed?

Furosemide is absorbed from the gastrointestinal tract, and its peak diuretic effect occurs between 1 and 1.5 hours after oral administration, and between 10 and 30 minutes after intravenous administration. Furosemide (>95%) binds to plasma proteins.

Does Lasix cause hypotension?

Furosemide can cause low blood pressure. A low-salt diet puts you at even higher risk of low blood pressure.

What is the mechanism of action of furosemide?

Furosemide, an anthranilic acid derivative, is a rapid acting, highly efficacious diuretic Rankin (2002). Its mechanism of action is inhibition of the sodium-potassium-2 chloride (Na+-K+-2 Cl−) co-transporter (symporter) located in the thick ascending limb of the loop of Henle in the renal tubule Jackson (1996).

Why is Lasix called Lasix?

Lasix – Short for “lasts 6 hours” because of its 6-hour duration of action.

Is furosemide good for kidneys?

Furosemide is given to help treat fluid retention (edema) and swelling that is caused by congestive heart failure, liver disease, kidney disease, or other medical conditions. It works by acting on the kidneys to increase the flow of urine.

Is Lasix hard on kidneys?

If it continues for a long time, the heart and arteries may not function properly. This can damage the blood vessels of the brain, heart, and kidneys, resulting in a stroke, heart failure, or kidney failure.

Does furosemide lower blood pressure?

This drug is also used to treat high blood pressure. Lowering high blood pressure helps prevent strokes, heart attacks, and kidney problems. Furosemide is a “water pill” (diuretic) that causes you to make more urine. This helps your body get rid of extra water and salt.