Which is major side effect of valproic acid?

Diarrhea, dizziness, drowsiness, hair loss, blurred/double vision, change in menstrual periods, ringing in the ears, shakiness (tremor), unsteadiness, weight changes may occur. If any of these effects persist or worsen, tell your doctor or pharmacist promptly.

What are the symptoms of vitamin C overdose?

Although too much dietary vitamin C is unlikely to be harmful, large doses of vitamin C supplements might cause:

  • Diarrhea.
  • Nausea.
  • Vomiting.
  • Heartburn.
  • Stomach (abdominal) cramps.
  • Headache.

What are the contraindications of valproic acid?

Valproic acid is contraindicated in patients with hepatic disorders, significant hepatic impairment, hypersensitivity to components of the drug and class of drug, urea cycle disorders, mitochondrial disorders, or suspected disorders in patients <2-year-old, and pregnancy (for migraine headache prophylaxis use of …

Which food supplement is best for weight gain?

The 4 Best Supplements to Gain Weight

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Does valproic acid increase blood pressure?

There are many known side effects of valproate including thrombocytopenia and hepatotoxicity [1]. Cardiovascular side effects are reported in 1–5% of patients taking valproate and include hypertension, tachycardia, and palpitations [2], though hypertensive urgency has not been previously described.

What is valproic acid toxicity?

In patients with a severe overdose of valproate, patients can present with hypotension, tachycardia, respiratory depression, metabolic acidosis, cerebral edema, and valproate-related hyperammonemic encephalopathy which may progress to coma and death, if not treated aggressively.

What is side effects of vitamin C?

Taking too much vitamin C can cause side effects, including:

  • Nausea, vomiting and diarrhea.
  • Heartburn.
  • Stomach cramps or bloating.
  • Fatigue and sleepiness, or sometimes insomnia.
  • Headache.
  • Skin flushing.

What should be monitored with valproic acid?

Obtain baseline complete blood cell counts with differential (CBC with diff); liver function tests, and pregnancy test for females. Monitor Depakote levels, liver function tests, and CBC with diff every 3-6 months. Monitor for development of polycystic ovary disease in females.

Can valproic acid cause hypotension?

Some studies have reported that infusion of valproate sodium is generally well tolerated, whereas other studies have reported various degrees of hypotension during infusion.