Can vinpocetine cause insomnia?

Side effects of vinpocetine may include indigestion, nausea, dizziness, anxiety, facial flushing, insomnia, headache, drowsiness, slower blood clotting, and a temporary drop in blood pressure, according to WebMD. Rigorous, long-term safety research in humans is lacking.

What does vinpocetine do in the brain?

In Europe, it’s sold as a drug called Cavinton. Vinpocetine might increase blood flow to the brain and protect brain cells (neurons) against injury. People use vinpocetine for memory, dementia, stroke, hearing loss, and many other conditions, but there is no good scientific evidence to support most of these uses.

Does vinpocetine increase dopamine?

In previous studies in striatum-isolated nerve endings (synaptosomes), we found that vinpocetine decreased dopamine (DA) at expense of its main metabolite 3,4-dihydroxyphenylacetic acid (DOPAC), and that 3-NPA increased DA, reactive oxygen species (ROS), DA-quinone products formation, and decreased DOPAC.

Does vinpocetine cross the blood brain barrier?

Vinpocetine can pass the blood-brain barrier and enter the brain after oral or intravenous administration (Gulyas et al., 2002a, Gulyas et al., 2002b).

What are the benefits of taking vinpocetine?

Vinpocetine inhibits PDE1 activity and improves cerebral blood flow by elevating cGMP and cAMP, increasing mitochondrial function, and improving glucose and oxygen utilization by the brain. Vinpocetine helps improve spatial memory in rats by preventing neuronal damage and favorably modulating cholinergic function (18).

Is vinpocetine a nootropic?

As a nootropic alkaloid, vinpocetine has been shown to facilitate learning and memory, specifically to prevent cognitive deficits commonly coupled with dementias [10,11]. Vinpocetine acts as a neuroprotective agent that reduces damage to the brain from ischemia, stroke, and trauma [12].

Is vinpocetine a Nootropic?

Can vinpocetine raise blood pressure?

Vinpocetine suppressed blood pressure elevation, which is in line with the vasodilatory effect that vinpocetine has [20]. However, blood pressure does not account for the atherosclerosis development in ApoE−/− mice [19]. Thus the anti-atherogenic effect of vinpocetine is likely mediated by its action on vessel walls.

Is vinpocetine good for tinnitus?

Lesser (Vinca minor) contains a compound known as vincamine. Extracts containing vincamine have been used in Germany to help decrease tinnitus. Preliminary clinical trial data show that vinpocetine, a semi-synthetic version of vincamine, can help reduce symptoms in people whose tinnitus is due to poor blood flow.

Is Huperzine the same as vinpocetine?

Huperzine inhibits AchE, which increases levels of the memory neurotransmitter acetylcholine. Vinpocetine increases cerebral oxygen and concentrations of ATP, and the firing rate of neurons associated with acetylcholine.

Does vinpocetine help tinnitus?

Does CoQ10 help with ringing in the ears?

For people who are deficient in CoQ10, supplementing with the nutrient may improve tinnitus. In a preliminary trial, supplementation with coenzyme Q10 (CoQ10) in the amount of 100 mg three times per day for 16 weeks significantly improved tinnitus in people who had initially low blood levels of CoQ10.