What is TGF beta used for?

Transforming growth factor β (TGF-β) is a highly pleiotropic cytokine that plays an important role in wound healing, angiogenesis, immunoregulation and cancer. The cells of the immune system produce the TGF-β1 isoform, which exerts powerful anti-inflammatory functions, and is a master regulator of the immune response.

What is the TGF-β paradox?

TGF-β regulates a wide range of biological functions including embryonic development, wound healing, organogenesis, immune modulation, and cancer progression. Interestingly, TGF-β is known to inhibit cell growth in benign cells but promote progression in cancer cells; this phenomenon is known as TGF-β paradox.

What is TGF beta inhibitor?

Transforming growth factor-β (TGF-β) is a multifunctional cytokine that is involved in proliferation, metastasis, and many other important processes in malignancy. Inhibitors targeting TGF-β have been considered by pharmaceutical companies for cancer therapy, and some of them are in clinical trial now.

Is TGF beta an oncogene or tumor suppressor?

TGF-β is a potent proliferation inhibitor of normal colon epithelial cells and acts as a tumor suppressor. However, TGF-β also promotes invasion and metastasis during late-stage CRC, thereby acting as an oncogene.

How do I lower my TGF B?

The main strategies for inhibition of TGF-β signaling pathway is to include compounds that interfere with the binding of TGF-β to its receptors, drugs that block intracellular signaling, and antisense oligonucleotides.

What causes high TGF beta?

What does it mean if your TGF-b1 result is too high? – TGF B-1 is often chronically over-expressed in disease states, including cancer, fibrosis and inflammation. – TGF B-1 is moderately to extremely high in Chronic Inflammatory Response Syndrome due to water-damaged buildings (CIRS).

What produces TGF?

TGF-beta is produced by many but not all parenchymal cell types, and is also produced or released by infiltrating cells such as lymphocytes, monocytes/macrophages, and platelets. Following wounding or inflammation, all these cells are potential sources of TGF-beta.

What does TGF b1 test for?

This is a quantitative EIA assay for the human cytokine Transforming Growth Factor beta 1 ( TGF ß-1). TGF β-1 plays a role in tissue regulation and is used as an aid to determine underlying causes of unusual or inflammatory disorders.

What is Jay Swinglers real name?

Jamie Michael “Jay” Swingler (born: March 17, 1995 (1995-03-17) [age 27]), is an English YouTuber who makes challenge, comedy and prank videos. Jay runs the channel TGFbro with Uncle Romell, where he uploads a variety of weird and random content for over 5 million subscribers.

Why did TGF get raided?

Two YouTubers have been charged with dangerous driving over a video posted online earlier this year. James ‘Jay’ Swingler, from Ercall in Telford, and Romell Henry, from Dudley, have been summonsed to appear at Kidderminster Magistrates Court.