What is liposome encapsulation?

Liposomal encapsulation is a process where fats are utilized to help bring important vitamins or medicines to certain parts of the body in little bubbles without impacting other parts of the body.

What is the liposomal technology designed to do?

The LIPOSHELL® technology allows to design the sizes of liposomes depending on the intended use (oral formulations: food supplements, drugs; injections; topical application: medical devices). They are built of lipid bilayer membrane filled with aqueous phase.

How is encapsulation efficiency of liposomes calculated?

Determination of encapsulation efficiency The encapsulation efficiency expressed as entrapment percentage was calculated through the following relationship: Encapsulation efficiency % = Total drug − free drug Total drug × 100 .

What is liposomal delivery technology?

Abstract. Liposomes are delivery vehicles for transporting substances into the body effectively via facilitating absorption directly in the mouth or by preventing breakdown by stomach acid.

What is liposomal encapsulated vitamin C?

Put simply, liposomal vitamin C is vitamin C which is contained within a liposome – a spherical vesicle containing fats (or lipids, hence the name). Liposomes mimic the cell membranes within the body, which is what helps to deliver the ingredients into the desired cells via the digestive system.

What are the main components of a liposomes?

Phospholipids are the main component of liposomes, which are amphiphilic molecules with hydrophobic tail and hydrophilic head group. The head groups of phospholipids are hydrophilic, while their fatty acid tails are usually acyl chains and hydrophobic.

What are the disadvantages of liposomes?

Disadvantages of liposomes Leakage and fusion of encapsulated drug / molecules. > Sometimes phospholipid undergoes oxidation and hydrolysis-like reactions.

Are liposomes natural or synthetic?

Liposome involves an aqueous core entrapped by one or more bilayers composed of natural or synthetic lipids. They are composed of natural phospholipids that are biologically inert and feebly immunogenic, and they have low inherent toxicity.

What is encapsulation efficiency?

Encapsulation efficiency is the percentage of drug that is successfully entrapped into the micelle or nanoparticle. Encapsulation efficiency (EE%) is calculated by (total drug added – free non-entrapped drug) divided by the total drug added.

How can encapsulation efficiency be improved?

For the hydrophilic drug, make the preparation method to be double-emulsion, the internal aqueous phase: change the pH to make the drug non-ionized, same goes to the outer aqueous phase. This will change the solubility of the drug to become less soluble in the buffer and hence higher EE is expected.

How does liposomal drug delivery work?

Abstract. Liposomes are a novel drug delivery system (NDDS), they are vesicular structures consisting of bilalyers which form spontaneously when phospholipids are dispersed in water. They are microscopic vesicles in which an aqueous volume is entirely enclosed by a membrane composed of lipid bilayers.