What is friability test formula?

Friability (%) = W1 – W2/ W1 X 100. Where, W1 = Weight of Tablets (Initial / Before Tumbling) & W2 = Weight of Tablets (After Tumbling or friability) Limit : Friability (%) = Not More Than 1.0 %

Why perform is friability test?

Friability is defined as the percentage of weight loss of powder from the surface of the tablets due to mechanical action and the test is performed to measure the weight loss during transportation .

What is the friability test limit?

1.0%
As per the formula, the limits of the friability test shall not be more than 1.0%.

What is disintegration time?

Disintegration time is the time needed for the drug to break into fragments under certain conditions. Some disintegration tests are done with simulated gastric or intestinal fluid to see how the dosages will perform when ingested.

What is DT and dissolution?

Definition. Disintegration is a process of breaking down a substance into tiny fragments to improve its solubility in a solvent. The process is used predominantly in pharmaceutical and chemical industries. Dissolution, on the other hand, is a process through which solutes dissolve in a solvent.

What is disintegration temperature?

An overlooked aspect in tablets disintegration is temperature. The average body temperature generally ranges between 35.8 to 37.2°C (Hasday and Singh, 2000). Therefore, in vitro disintegration studies could be simply modelled at 37°C.

What is unit of hardness?

The SI unit of hardness is N/mm². The unit Pascal is thus used for hardness as well but hardness must not be confused with pressure. The different types of hardness discussed above have different scales of measurement.

What is KP in hardness?

Typical hardness measurement units include: kiloponds (kp), Strong Cobb Units (SCU), and Newtons (N). The kilopond is defined as the force exerted by a kilogram mass upon its support in a gravitational field of g=9.80665 m/second2. One kilopond is equal to 9.807 N units or 1.4 SCU.

What is dissolution time?

The mean disintegration time (MDGT; mean time required for disintegration of tablets) and mean dissolution time (MDST; mean time required for drug dissolution) of water-soluble drugs from solid dosage forms were determined by moment analysis using microcalorimetric curves.

What is USP disintegration?

Complete disintegration is defined as that state in which any residue of the unit, except fragments of insoluble coating or capsule shell, remaining on the screen of the test apparatus or adhering to the lower surface of the disk, if used, is a soft mass having no palpably firm core. Change to read: APPARATUS.

Is ppm unit of hardness?

In the U.S., hardness is usually measured in ppm (parts-per-million), the molar concentration of CaCO3 which can be given by most test kits.