Does theophylline dissolve in water?
Does theophylline dissolve in water?
Theophylline is lightly soluble in water; soluble in hot water; sparingly soluble in alcohol, chloroform, and ether. It is freely soluble in alkali hydroxide solutions and in ammonia Sweetman (2002).
What is theophylline soluble in?
Theophylline dissolves in 1 M NH4OH at 50 mg/ml to yield a clear, colorless solution. It is soluble in 0.1 M HCl, 0.1 M NaOH and is slightly soluble(8.3 mg/ml) in water. It is also moderately soluble in ethanol.
Which is the elimination half life of theophylline?
Theophylline
| Clinical data | |
|---|---|
| Protein binding | 40% (primarily to albumin) |
| Metabolism | Hepatic to 1-methyluric acid |
| Elimination half-life | 5–8 hours |
| Identifiers |
Is theophylline a prodrug?
Theophylline (Th-H) was the first amide/imide for which prodrugs were synthesized and characterized for their ability to enhance the topical delivery of their parent drug from a lipid vehicle isopropyl myristate (IPM) (1,2).
What is theophylline anhydrous?
Uniphyl (theophylline, anhydrous) is a bronchodilator used to treat the symptoms of asthma, bronchitis, and emphysema. The brand name Uniphyl is discontinued, but generic versions may be available.
Is theophylline lipophilic or hydrophilic?
The objective of the current study was to co-encapsulate a hydrophilic drug (theophylline) and a lipophilic drug (budesonide) in poly(lactic acid) (PLA) nanoparticles for pulmonary drug delivery.
How is theophylline metabolised?
Theophylline is metabolized in the liver by the cytochrome P450 microsomal enzyme system, and a large number of factors may influence hepatic metabolism. Theophylline is predominantly metabolized by the CYP1A2 enzyme, while at higher plasma concentrations CYP2E1 is also involved (89).
How is theophylline excreted?
Beyond the first three months of life, approximately 10% of the Theophylline dose is excreted unchanged in the urine. The remainder is excreted in the urine mainly as 1,3-dimethyluric acid (35 to 40%), 1-methyluric acid (20 to 25%) and 3-methylxanthine (15 to 20%).
Can theophylline be crushed?
Do not crush or chew the capsules or tablets. Doing so can release all of the drug at once, increasing the risk of side effects. Also, do not split the tablets unless they have a score line and your doctor or pharmacist tells you to do so. Swallow the whole or split tablet without crushing or chewing.
What is theophylline anhydrous 200 Kiara used for?
Theophylline is a bronchodilator that is used to treat symptoms of asthma, bronchitis, emphysema, and other breathing problems. Theophylline may also be used for purposes not listed in this medication guide.
Is theophylline an acid or base?
Theophylline is an extremely weak basic (essentially neutral) compound (based on its pKa). Theophylline is a bitter tasting compound. Theophylline is found, on average, in the highest concentration within cocoa beans and tea.
What is theophylline anhydrous used for?
Uniphyl (theophylline, anhydrous) is a bronchodilator used to treat the symptoms of asthma, bronchitis, and emphysema.
