Is meropenem safe for neonates?
Is meropenem safe for neonates?
Meropenem has activity against wide variety of Gram-negative and Gram-positive bacteria. It is well tolerated by children and neonates, including preterm babies, and allowing monotherapy instead of combined therapy.
Is meropenem safe in children?
Several studies have demonstrated that meropenem is an effective and safe treatment for infants and children with serious pediatric infections (e.g., urinary tract infections, pneumonia, sepsis, intraabdominal infections, and skin and soft-tissue infections), bacterial meningitis, and cystic fibrosis.
What are the adverse effects in administering meropenem among infants?
Possible adverse effects
- Leukopenia, neutropenia, eosinophillia, thrombocytopenia and anaemia.
- Inflammation at injection site.
- Vomiting, diarrhoea, and constipation (1%).
- Rash (2%).
- Nephrotoxicity, hepatotoxicity.
Why is meropenem given slowly?
Studies have suggested that a smaller dose given over a longer period of time, results in blood levels of meropenem that are just as good as when a higher dose is given over a shorter period of time.
What are the contraindications of meropenem?
Who should not take MEROPENEM?
- diarrhea from an infection with Clostridium difficile bacteria.
- decreased blood platelets.
- lesion of the brain.
- seizures.
- chronic kidney disease stage 4 (severe)
- chronic kidney disease stage 5 (failure)
- kidney disease with likely reduction in kidney function.
How long should meropenem be given?
The recommended duration of therapy is 7 days for Neisseria meningitidis and Haemophilus influenzae, 10 to 14 days for Streptococcus pneumoniae, and at least 3 weeks for gram-negative bacilli. Limited data are available; 40 mg/kg/dose IV every 8 or 12 hours is the most commonly reported dosage.
Who should not take meropenem?
Pediatric. Appropriate studies performed to date have not demonstrated pediatric-specific problems that would limit the usefulness of meropenem injection in children 3 months of age and older with complicated skin and skin structure infections and bacterial meningitis, and for children with intra-abdominal infections.
Can meropenem cause seizures?
For meropenem, doripenem, and ertapenem, the seizure rate for each agent is reported as less than 1%. However, as their use increases and expands into new patient populations, the rate of seizures with these agents may increase.
Is meropenem a strong antibiotic?
Meropenem (Merrem) is considered one of the stronger antibiotics. It works against many types of bacteria and treats severe or complicated infections when other antibiotics may not be enough.
When should you not use meropenem?
Who should not take MEROPENEM?
- diarrhea from an infection with Clostridium difficile bacteria.
- decreased blood platelets.
- lesion of the brain.
- seizures.
- chronic kidney disease stage 4 (severe)
- chronic kidney disease stage 5 (failure)
- kidney disease with likely reduction in kidney function.
Can meropenem cause death?
Deaths in 5 patients were assessed as possibly related to meropenem; 36 (1.2%) patients had meropenem discontinued because of adverse events. Many patients in these trials were severely ill and had multiple background diseases, physiological impairments and were receiving multiple other drug therapies.
Why is meropenem given?
Meropenem injection is used to treat skin and abdominal (stomach area) infections caused by bacteria and meningitis (infection of the membranes that surround the brain and spinal cord) in adults and children 3 months of age and older. Meropenem injection is in a class of medications called antibiotics.
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