How is Inapsine administered?

How is Inapsine administered?

Adult dosage: The maximum recommended initial dose of INAPSINE (droperidol) is 2.5 mg IM or slow IV. Additional 1.25 mg doses of INAPSINE (droperidol) may be administered to achieve the desired effect.

Why was droperidol taken off the market?

The FDA’s decision led to the substantial decline in routine droperidol use as hospital systems and practitioners looked elsewhere for alternatives devoid of the increased risk of cardiac issues and overly burdensome monitoring requirements.

How do you administer droperidol?

Maximum Dosage: The maximum recommended initial dose is 2.5 mg IM or slow IV. Additional 1.25 mg doses of droperidol may be administered to achieve the desired effect. The additional doses should be administered with caution and only if the potential benefit outweighs the potential risk.

How fast do you push droperidol?

Onset of action can be expected within 5–10 minutes IM, and a bit faster IV, though studies suggest full effects may not be apparent for up to 20–30 minutes, at which time redosing can be considered.

Why does droperidol have a black box warning?

Anesthesiologists have used droperidol off-label for the last 30 yr for the prevention and treatment of postoperative nausea and vomiting. In 2001, a “black box” warning was added to the droperidol package insert due to concerns of prolonged QT and ventricular arrhythmias, specifically torsades de pointes.

What does droperidol feel like?

fast or pounding heartbeats, fluttering in your chest, shortness of breath, and sudden dizziness (like you might pass out); slow heart rate, weak pulse, fainting, slow breathing (breathing may stop); confusion, hallucinations; bronchospasm (wheezing, chest tightness, trouble breathing);

Can you give droperidol IV push?

NOTE: Due to a risk of QT prolongation and torsade de pointes, the approved indication of droperidol is limited to the prevention of surgical nausea and vomiting. Usage outside of the labeled indication and administration routes is not recommended. Administer intramuscularly or intravenously via slow IV administration.

Is droperidol off the market?

Droperidol was reintroduced to the US market in February 2019 by American Regent, still with the black box warning. Several months later, the company was reporting shortages of the drug, although the website currently states that it is available.

What class of drug is droperidol?

Droperidol

What is Inapsine?

INAPSINE is a sterile, non-pyrogenic, aqueous solution for intravenous or intramuscular injection. INAPSINE (droperidol) produces marked tranquilization and sedation. It allays apprehension and provides a state of mental detachment and indifference while maintaining a state of reflex

What is Inapsine used for in dogs?

Inapsine (droperidol) produces marked tranquilization and sedation. It allays apprehension and provides a state of mental detachment and indifference while maintaining a state of reflex alertness. Inapsine produces an antiemetic effect as evidenced by the antagonism of apomorphine in dogs.

What is the lethal dose of Inapsine?

If significant extrapyramidal reactions occur in the context of an overdose, an anticholinergic should be administered. The intravenous Median Lethal Dose of INAPSINE is 20 to 43 mg/kg in mice; 30 mg/kg in rats; 25 mg/kg in dogs and 11 to 13 mg/kg in rabbits.

What are possible pharmacodynamic interactions between Inapsine and other medications?

Possible pharmacodynamic interactions can occur between Inapsine and potentially arrhythmogenic agents such as class I or III antiarrhythmics, antihistamines that prolong the QT interval, antimalarials, calcium channel blockers, neuroleptics that prolong the QT interval, and antidepressants.