What is posttraumatic hypopituitarism?

Posttraumatic hypopituitarism is associated with an unfavorable body composition and lipid profile, and decreased quality of life 12 months after injury. J Clin Endocrinol Metab (2007) 92(10):3861–8.10.1210/jc.2007-0901 [PubMed] [CrossRef] [Google Scholar] 29.

What are the symptoms of hypopituitarism?

Signs and symptoms of hypopituitarism vary from person to person, depending on which pituitary hormones are affected and to what degree….Most adults who have GH deficiency don’t have any symptoms, but for some adults it can cause:

  • Fatigue.
  • Muscle weakness.
  • Changes in body fat composition.
  • Lack of ambition.
  • Social isolation.

Does GHD affect the brain?

Since high levels of GHRs and IGF1 receptors are found in brain regions that are known to be of importance in cognitive functioning, e.g. the hippocampus, amygdala and parahippocampal areas, GHD may affect cognitive function and GH replacement therapy may counteract these alterations in cognitive performance (10).

Can a head trauma damage the pituitary gland?

Head injury can damage the pituitary gland and reduce production of two important hormones. The part of the pituitary gland that regulates growth hormone (GH) release is particularly vulnerable to the effects of head injury.

How is hypopituitarism treated?

Treatment

  1. Corticosteroids. These drugs, such as hydrocortisone (Cortef) or prednisone (Rayos), replace the adrenal hormones that aren’t being produced because of an adrenocorticotropic hormone (ACTH) deficiency.
  2. Levothyroxine (Levoxyl, Synthroid, others).
  3. Sex hormones.
  4. Growth hormone.
  5. Fertility hormones.

How serious is hypopituitarism?

Hypopituitarism, a disease of varied etiologies, is a serious endocrine illness that requires early recognition and prompt treatment to avoid its severe deleterious effects.

What is the most common cause of hypopituitarism?

Pituitary adenomas: One of the most common causes of primary hypopituitarism is a pituitary adenoma (a benign, or noncancerous, tumor).

How common is GHD in adults?

Incidence: Growth hormone deficiency is relatively rare. About one in 4,000 to 6,000 children have GHD, and it affects about 50,000 U.S. adults.

Can MRI show pituitary damage?

Magnetic resonance imaging (MRI) scan MRI images are usually more detailed than those from CT scans (see below). They can show macroadenomas of the pituitary gland, as well as most microadenomas.

Does hypopituitarism shorten your life?

Growing, but not completely conclusive, evidence indicates that childhood hypopituitarism may be associated with a shortened adult lifespan, even with adequate hormonal replacement.

Is post-traumatic hypopituitarism (pthp) under-diagnosed?

Over the last 15 years, a significant body of evidence has emerged demonstrating that post-traumatic hypopituitarism (PTHP) is a common and clinically significant consequence of TBI. Non-specific symptomology and the lack of an agreed approach to screening for PTHP has led to significant under-diagnosis of this debilitating disease.

Does mild traumatic brain injury cause hypopituitarism?

The most robust data with regard to incidence of PTHP are in those patients with moderate or severe TBI (14). We therefore do not routinely screen patients with mild TBI for pituitary dysfunction unless there are specific symptoms suggestive of hypopituitarism (21, 22).

What is the history of hypopituitarism?

Keywords: hypopituitarism, combined pituitary hormone deficiency, isolated growth hormone deficiency, post-traumatic hypopituitarism, vascularization, Sheehan`s syndrome Introduction Hypopituitarism is defined as a diminished function of the pituitary gland. First described in 1914 by Simmonds, it is also known as Simmonds’ disease 1.

What is hypopituitarism (Simmonds disease)?

Introduction Hypopituitarism is defined as a diminished function of the pituitary gland. First described in 1914 by Simmonds, it is also known as Simmonds’ disease 1. There are two main reasons for the hypofunction of the pituitary gland: it can result from pituitary dysfunction per seor from hypothalamic damage.