Does retinoic acid cause birth defects?

It is indicated for severe cystic acne treatment, but it has been classified as teratogenic. A wide spectrum of birth defects including craniofacial, heart, and nervous system malformations have been described with prenatal exposure to this drug.

What happens to babies born on Accutane?

Birth defects which have been documented following Accutane exposure include abnormalities of the face, eyes, ears, skull, central nervous system, cardiovascular system, and thymus and parathyroid glands. Cases of IQ scores less than 85 with or without other abnormalities have been reported.

Can you have a baby after Accutane?

In healthy adults, it takes up to 10 days, on average, for most of the isotretinoin and its by-products to be gone from the body. However, it is recommended that a person wait one month after stopping isotretinoin before trying to get pregnant.

Why can’t you have a baby on Accutane?

Accutane, also known as isotretinoin, is known to cause birth defects, including brain, heart, and face deformities, if women take it while pregnant. Because of this, it is recommended that women of childbearing age taking the drug be tested for pregnancy before starting it and then repeatedly during their treatment.

What is isotretinoin (13-cis-retinoic acid)?

Isotretinoin, also known as 13-cis-retinoic acid and sold under the brand name Accutane among others, is a medication primarily used to treat severe acne. It is also used to prevent certain skin cancers ( squamous-cell carcinoma ), and in the treatment of other cancers.

What is the CID number for Accutane (isotretinoin)?

S2CID 8475675. ^ a b c d e “FDA information, side effects, and uses / Accutane (isotretinoin)”. U. S. Food and Drug Administration (FDA).

Is Accutane (isotretinoin) a teratogen?

Isotretinoin (Accutane) as a Teratogen. Such disruptions can lead to developmental defects, particularly in the embryonic spinal cord, central nervous system, and spinal cord, where retinoic acid synthesizes and where catabolic enzymes are located.

How many babies have been born with birth defects due to isotretinoin?

In early 1988 the FDA called for another advisory committee, and FDA employees prepared an internal memo estimating that around 1,000 babies had been born with birth defects due to isotretinoin, that up to around 1,000 miscarriages had been caused, and that between 5,000 and 7,000 women had had abortions due to isotretinoin.