What is beta-catenin stain?

Our results indicate that nuclear β-catenin staining is a sensitive marker for desmoid-type fibromatosis, and when high-level staining is seen, it is quite specific for this tumor type, although a few other tumor types may also show such staining.

How is beta-catenin activated?

The Wnt system is 1 of the well-known potent pathways, which activates nuclear β-catenin. In the absence of Wnt signal, free cytoplasmic β-catenin is phosphorylated by serine/threonine kinases, casein Kinase Iα (CKIα) and GSK3β in a large APC/axin scaffolding complex that targets β-catenin for degradation.

What is the role of beta-catenin?

In the canonical Wnt cascade, β-catenin is the key effector responsible for transduction of the signal to the nucleus and it triggers transcription of Wnt-specific genes responsible for the control of cell fate decisions in many cells and tissues.

What does beta catenin bind to?

β-Catenin interacts with the transcription factor, T-cell factor/lymphoid enhancer-binding factor, and regulates the transcription of various target genes associated with cell survival, proliferation, metastasis, and EMT [58].

What is beta catenin signaling?

Wnt/β-catenin signaling, a highly conserved pathway through evolution, regulates key cellular functions including proliferation, differentiation, migration, genetic stability, apoptosis, and stem cell renewal.

What does Wnt gene do?

Wnt proteins are secreted, lipid-modified glycoproteins that allow for communication between cells. They regulate cell growth, function, differentiation, and cell death. Wnt proteins play a central role in bone development, modeling, and remodeling.

What is beta-catenin signaling?

What happens when there is too much beta-catenin?

We report here that overexpression of beta-catenin results in accumulation of p53, apparently through interference with its proteolytic degradation. This effect involves both Mdm2-dependent and -independent p53 degradation pathways, and is accompanied by augmented transcriptional activity of p53 in the affected cells.