What does high inhibin A mean?

Conclusions. High levels of maternal serum inhibin-A in the second trimester are significantly associated with abnormal placentation, which increases the risk of preeclampsia and FGR with a consequence of indicated preterm birth but not a risk of spontaneous preterm birth.

What is the normal range for inhibin A in pregnancy?

The normal range of inhibin A at 15–19 weeks was 41.4–690 pg/ml and at 21–25 weeks was 47.6–1719 pg/ml. The normal ranges of activin A at 15–19 weeks and 21–25 weeks were 0.64–15.71 and 0.86–28.74 ng/ml.

Does high inhibin a mean Down syndrome?

An inhibin A level > or = 1.6 multiples of the median identified 70% of all Down syndrome pregnancies at a false-positive rate of 22%. Replacing estriol with inhibin A in the multiple-marker screening test resulted in a higher Down syndrome detection rate at a lower screen-positive rate.

What causes high inhibin A in pregnancy?

The level of elevated Inhibin A in pregnancy is significantly related to the outcome of pre-eclampsia, GDM, macrosomia, low birth weight and preterm delivery.

What causes high inhibin levels?

Elevated levels of inhibin A and/or inhibin B may be present in the blood of a woman with a rare type of ovarian tumor called a granulosa cell tumor (the most common type of sex-cord stromal tumor). Blood levels of these hormones may also be elevated in some women with mucinous epithelial tumors.

What does inhibin A test for?

The inhibin A test is done to measure the amount of this hormone in a pregnant woman’s blood to see if the baby may have Down syndrome. Inhibin A is made by the placenta during pregnancy. The level of inhibin A in the blood is used in a maternal serum quadruple screening test.

What is inhibin A in Down syndrome?

Inhibin A is a maternal serum marker for fetal Down’s syndrome (DS) in the second trimester. We examined whether inhibin A could be used early in the first trimester. Maternal serum concentrations of inhibin A were determined in 81 controls and 27 cases of fetal trisomy 21 in gestational week 5-11.

Is inhibin A elevated for Down syndrome?

The serum levels of inhibin A were elevated in the women whose fetuses were affected by Down’s syndrome, with an overall median value 2.06 times the median among the women with normal pregnancies (by the Mann–Whitney test, P<0.001).

When do high hCG levels indicate Down syndrome?

They concluded that high hCG levels were associated with Down’s syndrome and because hCG levels plateau at 18 to 24 weeks, that this would be the most appropriate time for screening. Later work suggested that the ß subunit of hCG was a more effective marker than total hCG (Macri 1990; Macri 1993).