What is distribution coefficient in solvent extraction?

The distribution coefficient is the ratio of the concentration of solute in the organic phase over the concentration of solute in the aqueous phase (the V-terms are the volume of the phases).

What is the distribution coefficient for the solute?

The distribution coefficient is defined as the concentration of solute in the organic solvent divided by the concentration of solute in the aqueous phase.

What is meant by distribution coefficient in chromatography?

The distribution constant, also called partition coefficient, is defined for a given chemical compound in a specific chromatographic system. It is the ratio of the solute concentration in the stationary phase to its concentration in the mobile phase, as shown in Equation 8-1 [8]: (Equation 8-1)

What is the relationship between solubility and partition coefficient?

The greater the solubility of a substance, the higher its partition coefficient, and the higher the partition coefficient, the higher the permeability of the membrane to that particular substance.

What is the use of distribution coefficient?

The use of distribution coefficients (log D) for the analysis of structure-activity relationships of ionizable compounds is described. (D is the ratio of the equilibrium concentration of compound in an organic phase to the total concentration of un-ionized and ionized species in the aqueous phase at a given pH.)

How do you calculate distribution coefficient in extraction?

The ratio of solubilities in the two solvents is called the distribution coefficient, KD = C1/C2, which is an equilibrium constant with a characteristic value for any compound at a given temperature. The total amount extracted by 100 mL as 2 x 50 mL portions of ether is thus 0.92 g.

What does the distribution coefficient tell you?

Thus, the partition-coefficient or the distribution-coefficient is the ratio of the respective equilibrium concentrations of a chemical in a mixture of two immiscible phases and is also a measure of the difference in solubility of the chemical in the two phases.

How does the partition coefficient affect the solubility of the drug?

It describes the partition of an agent between a gaseous phase, such as alveolar air, and the blood. The greater the blood:gas partition coefficient, the greater the solubility in blood. The oil:gas partition coefficient has been correlated to anesthetic potency – the higher the coefficient, the more potent the agent.

What does distribution coefficient 1 mean?

chemical separation …described in terms of the distribution coefficient, K, by the equationin which the concentrations in the equilibrium state are considered. For K = 1, there are equal concentrations of the dye in the two phases; for K > 1, more dye would be found in the benzene phase at equilibrium.…

What is the pharmaceutical importance of partition coefficient?

Partition coefficients are used in the pharmaceutical industry to estimate how a drug may transfer between different biological environments4,20 and are regularly used to predict a molecule’s hydrophobicity.