What is horse anti-thymocyte globulin?
What is horse anti-thymocyte globulin?
What is this medicine? ANTI-THYMOCYTE IMMUNE GLOBULIN (an tee THI mo cite im MUNE GLOB yoo lin) weakens the body’s immune system. This medicine is used to prevent and to treat kidney transplant rejection. It is also used to treat aplastic anemia.
What is Atgam drug?
Atgam is a polyclonal antibody, or an immune globulin, given as an intravenous (IV, into a vein) infusion. Atgam is used to fight a type of white blood cell called a T-lymphocyte (also called a thymocyte or T-cell). T-lymphocytes are part of your immune system.
How long does it take Atgam to work?
If it works, ATG usually stops the need for blood transfusions within 3 months. Full success can take at least 9 months. Some patients may respond initially, but may later relapse and need another treatment.
How much does Antithymocyte globulin cost?
The costs for basiliximab and antithymocyte globulin were calculated based on average wholesale prices (AWP). The price of basiliximab was $1224 per dose and the price of antithymocyte globulin was $262.24 per 250 mg ampoule [9].
What is ATG in transplant?
Antithymocyte globulin (ATG) is an antibody preparation derived from rabbits or horses hyperimmunized with human thymocytes, which is used to prevent or treat acute cellular rejection after solid organ transplantation and as a therapy of acute aplastic anemia.
Is Atgam hazardous?
Inform patients that Atgam may cause serious allergic reactions, infection or abnormal liver or renal function. Advise the patient to discontinue Atgam and seek immediate medical attention if any signs/symptoms of an allergic or immune reaction occur [see Warnings and Precautions (5.1)].
How is Atgam administered?
ATGAM is appropriately administered into a vascular shunt, arterial venous fistula, or a high-flow central vein using an in-line filter with a pore size of 0.2 to 1.0 micron.
Is fludarabine a chemotherapy?
Fludarabine is a chemotherapy drug and has the brand name Fludara. Fludarabine is mainly used to treat chronic lymphocytic leukaemia (CLL).
How much are antirejection drugs?
Antirejection medications are critical in maintaining the transplanted organ. During the first year after transplant, anti-rejection drugs can cost from $1,500 to 1,800 per month.
Are immunosuppressant drugs expensive?
The average cost of immunosuppressants is between $10,000 to $14,000 per year (4).
What is ATG made of?
Introduction. Antithymocyte globulin (ATG) is an antibody preparation derived from rabbits or horses hyperimmunized with human thymocytes, which is used to prevent or treat acute cellular rejection after solid organ transplantation and as a therapy of acute aplastic anemia.
How do you administer an ATG?
ATG (rabbit) is administered by IV infusion. The manufacturer states that ATG (rabbit) should be infused through an inline 0.22-μm filter into a high-flow vein. Has also been administered via a peripheral vein† in some patients, but safety not fully established and may increase risk of thrombophlebitis and DVT.
